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Complete protection by a single dose skin patch delivered SARS-CoV-2 spike vaccine
Christopher L.D. McMillan; Jovin J.Y. Choo; Adi Idris; Aroon Supramaniam; Naphak Modhiran; Alberto A Amarilla; Ariel Isaacs; Stacey T.M. Cheung; Benjamin Liang; Helle Bielefeldt-Ohmann; Armira Azuar; Dhruba Acharya; Gabrielle Kelly; Germain J.P. Fernando; Michael J. Landsberg; Alexander A Khromykh; Daniel Watterson; Paul R. Young; Nigel A.J. McMillan; David A Muller.
  • Christopher L.D. McMillan; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Jovin J.Y. Choo; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Adi Idris; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University
  • Aroon Supramaniam; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University
  • Naphak Modhiran; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Alberto A Amarilla; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Ariel Isaacs; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Stacey T.M. Cheung; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Benjamin Liang; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Helle Bielefeldt-Ohmann; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Armira Azuar; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Dhruba Acharya; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University
  • Gabrielle Kelly; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University
  • Germain J.P. Fernando; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Michael J. Landsberg; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Alexander A Khromykh; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Daniel Watterson; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Paul R. Young; School of Chemistry and Molecular Biosciences, The University of Queensland
  • Nigel A.J. McMillan; Menzies Health Institute Queensland, School of Pharmacy, Anatomy and Medical Sciences, Griffith University
  • David A Muller; The University of Queensland
Preprint in English | bioRxiv | ID: ppbiorxiv-446357
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ABSTRACT
SARS-CoV-2 has infected over 160 million people and resulted in more than 3.3 million deaths, and we still face many challenges in the rollout of vaccines. Here, we use the high-density microarray patch to deliver a SARS-CoV-2 spike subunit vaccine directly to the skin. We show the vaccine, dry-coated on the patch is thermostable, and delivery of spike via HD-MAP induced greater cellular and antibody immune responses, with serum able to potently neutralize clinically relevant isolates including those from the B.1.1.7 and B.1.351 lineages. Finally, a single dose of HD-MAP-delivered spike provided complete protection from a lethal virus challenge, demonstrating that HD-MAP delivery of a SARS-CoV-2 vaccine is superior to traditional needle-and-syringe vaccination and has the potential to greatly impact the ongoing COVID-19 pandemic.
Full text: Available Collection: Preprints Database: bioRxiv Topics: Vaccines Language: English Year: 2021 Document Type: Preprint

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Full text: Available Collection: Preprints Database: bioRxiv Topics: Vaccines Language: English Year: 2021 Document Type: Preprint