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A single dose of an adenovirus-vectored vaccine provides complete protection of the upper and lower respiratory tracts against SARS-CoV-2 challenge
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-324160
ABSTRACT
The unprecedented coronavirus disease 2019 (COVID-19) epidemic has created a worldwide public health emergency, and there is an urgent need to develop an effective vaccine to control this severe infectious disease. Here, we found that a single vaccination with a replication-defective human type 5 adenovirus encoding the SARS-CoV-2 spike protein (Ad5-nCoV) protected mice completely against SARS-CoV-2 infection in the upper and lower respiratory tracts. Additionally, a single vaccination with Ad5-nCoV protected ferrets from SARS-CoV-2 infection in the upper respiratory tract. This study suggested that a combination of intramuscular and mucosal vaccination maybe provide a desirable protective efficacy and different Ad5-nCoV delivery modes are worth further investigation in human clinical trials.

Full text: Available Collection: Preprints Database: EuropePMC Topics: Vaccines Language: English Year: 2020 Document Type: Preprint

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Full text: Available Collection: Preprints Database: EuropePMC Topics: Vaccines Language: English Year: 2020 Document Type: Preprint