Your browser doesn't support javascript.
Impact of HIV Infection on COVID-19 Outcomes Among Hospitalized Adults in the U.S (preprint)
MEDLINE;
Preprint in English | MEDLINE | ID: ppcovidwho-326640
ABSTRACT

Background:

Whether HIV infection is associated with differences in clinical outcomes among people hospitalized with COVID-19 is uncertain.

Objective:

To evaluate the impact of HIV infection on COVID-19 outcomes among hospitalized patients.

Methods:

Using the American Heart Association's COVID-19 Cardiovascular Disease registry, we used hierarchical mixed effects models to assess the association of HIV with in-hospital mortality accounting for patient demographics and comorbidities and clustering by hospital. Secondary outcomes included major adverse cardiac events (MACE), severity of illness, and length of stay (LOS).

Results:

The registry included 21,528 hospitalization records of people with confirmed COVID-19 from 107 hospitals in 2020, including 220 people living with HIV (PLWH). PLWH were younger (56.0+/-13.0 versus 61.3+/-17.9 years old) and more likely to be male (72.3% vs 52.7%), Non-Hispanic Black (51.4% vs 25.4%), on Medicaid (44.5% vs 24.5), and active tobacco users (12.7% versus 6.5%). Of the study population, 36 PLWH (16.4%) had in-hospital mortality compared with 3,290 (15.4%) without HIV (Risk ratio 1.06, 95%CI 0.79-1.43;risk difference 0.9%, 95%CI -4.2 to 6.1%;p=0.71). After adjustment for age, sex, race, and insurance, HIV was not associated with in-hospital mortality (aOR 1.13;95%CI 0.77-1.6;p 0.54) even after adding body mass index and comorbidities (aOR 1.15;95%CI 0.78-1.70;p=0.48). HIV was not associated with MACE (aOR 0.99, 95%CI 0.69-1.44, p=0.91), severity of illness (aOR 0.96, 95%CI 0.62-1.50, p=0.86), or LOS (aOR 1.03;95% CI 0.76-1.66, p=0.21).

Conclusion:

HIV was not associated with adverse outcomes of COVID-19 including in-hospital mortality, MACE, or severity of illness. Condensed Abstract We studied 21,528 patients hospitalized with COVID-19 at 107 hospitals in AHA's COVID-19 registry to examine the association between HIV and COVID-19 outcomes. More patients with HIV were younger, male, non-Hispanic Black, on Medicaid and current smokers. HIV was not associated with worse COVID-19 in-hospital mortality (Risk ratio 1.06, 95%CI 0.79-1.43;p=0.71) even after adjustment (aOR 1.15;95%CI 0.78-1.70;p=0.48). HIV was also not associated with MACE (aOR 0.99, 95%CI 0.69-1.44, p=0.91) or severity of illness (aOR 0.96, 95%CI 0.62-1.50, p=0.86. Our findings do not support that HIV is a major risk factor for adverse COVID-19 outcomes.

Full text: Available Collection: Preprints Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Document Type: Preprint

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: Preprints Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Document Type: Preprint