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Cross-neutralizing activity against Omicron could be obtained in SARS-CoV-2 convalescent patients who received two doses of mRNA vaccination (preprint)
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-329141
ABSTRACT
The SARS-CoV-2 variant Omicron is now under investigation. We evaluated cross-neutralizing activity against Omicron in COVID-19 convalescent patients (n=23) who had received two doses of an mRNA vaccination (BNT162b2 or mRNA-1273). Surprisingly and interestingly, after the second vaccination, the subjects’ neutralizing antibody titers including that against Omicron all became seropositive, and significant fold-increases (21.1–52.0) were seen regardless of the subjects’ disease severity. Our findings thus demonstrate that at least two doses of mRNA vaccination to SARS-CoV-2 convalescent patients can induce cross-neutralizing activity against Omicron.

Full text: Available Collection: Preprints Database: EuropePMC Type of study: Randomized controlled trials Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Preprint

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Full text: Available Collection: Preprints Database: EuropePMC Type of study: Randomized controlled trials Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Preprint