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Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster (preprint)
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-329675
ABSTRACT
With the development of COVID-19, even though increased global vaccination coverage, a super variant of SARS-CoV-2, Omicron, carrying a great number of mutations, has been verified its strong capacity of immune escape. An increased risk of SARS-CoV-2 reinfection or breakthrough infection should be concerned. We analyzed the humoral immune response of Omicron breakthrough infection and found its cross-neutralization against VOCs. We established mouse models to verify whether Omicron-specific RBD subunit boost immune response by immunizing Omicron-RBD recombinant proteins. The results suggest that an additional boost vaccination with Omicron-RBD protein could increase humoral immune response against both WT and current VOCs.

Full text: Available Collection: Preprints Database: EuropePMC Type of study: Randomized controlled trials Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Preprint

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Full text: Available Collection: Preprints Database: EuropePMC Type of study: Randomized controlled trials Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Preprint