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Reliability of self-sampling for accurate assessment of respiratory virus viral and immunologic kinetics (preprint)
medrxiv; 2020.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2020.04.03.20051706
ABSTRACT
The SARS-CoV-2 pandemic demonstrates the need for accurate and convenient approaches to diagnose and therapeutically monitor respiratory viral infections. We demonstrated that self-sampling with foam swabs at home is well-tolerated and provides quantitative viral output concordant with flocked swabs. Nasal cytokine levels correlate and cluster according to immune cell of origin. Periods of stable viral loads are followed by rapid elimination, which could be coupled with cytokine expansion and contraction using mathematical models. Nasal foam swab self-sampling at home provides a precise, mechanistic readout of respiratory virus shedding and local immune responses.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Respiratory Tract Infections
Language:
English
Year:
2020
Document Type:
Preprint
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