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The prevalence of antibodies to SARS-CoV-2 among blood donors in China
Le Chang; Wanghen Hou; Lei Zhao; Yali Zhang; Yanbin Wang; Linfeng Wu; Tingting Xu; Lilin Wang; Juan Wang; Jian Ma; Lan Wang; Junpeng Zhao; Jing Xu; Juan Dong; Ying Yan; Ru Yang; Yu Li; Fei Guo; Wenjuan Cheng; Yingying Su; Jinfeng Zeng; Wei Han; Tong Cheng; Jun Zhang; Quan Yuan; Xia Ningshao; Lunan Wang.
  • Le Chang; National Center for Clinical Laboratories, Beijing Hospital
  • Wanghen Hou; School of Public Health, Xiamen University
  • Lei Zhao; Department of Laboratory, Wuhan Blood Center
  • Yali Zhang; School of Public Health, Xiamen University
  • Yanbin Wang; Blood Screenning Laboratory, Hebei Province Blood Center
  • Linfeng Wu; Shenzhen Blood Center
  • Tingting Xu; Department of Laboratory, Wuhan Blood Center
  • Lilin Wang; Shenzhen Blood Center
  • Juan Wang; School of Public Health, Xiamen University
  • Jian Ma; School of Public Health, Xiamen University
  • Lan Wang; Wuhan Blood Center
  • Junpeng Zhao; Shenzhen Blood Center
  • Jing Xu; Wuhan Blood Center
  • Juan Dong; Department of Laboratory, Wuhan Blood Center
  • Ying Yan; National Center for Clinical Laboratories, Beijing Hospital
  • Ru Yang; Department of Transfusion Research, Wuhan Blood Center
  • Yu Li; Department of Laboratory, Wuhan Blood Center
  • Fei Guo; National Center for Clinical Laboratories, Beijing Hospital
  • Wenjuan Cheng; Department of Laboratory, Wuhan Blood Center
  • Yingying Su; School of Public Health, Xiamen University
  • Jinfeng Zeng; Shenzhen Blood Center
  • Wei Han; Blood Screenning Laboratory, Hebei Province Blood Center
  • Tong Cheng; School of Public Health, Xiamen University
  • Jun Zhang; School of Public Health, Xiamen University
  • Quan Yuan; School of Public Health, Xiamen University
  • Xia Ningshao; School of Public Health, Xiamen University
  • Lunan Wang; National Center for Clinical Laboratories, Beijing Hospital
Preprint in English | medRxiv | ID: ppmedrxiv-20153106
Journal article
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ABSTRACT
ObjectivesThe prevalence of antibodies to SARS-CoV-2 among blood donors in China remains unknown. To reveal the missing information, we investigated the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang of China. DesignCross-sectional study SettingThree blood centers, located in the central, south and north China, respectively, recruiting from January to April 2020. Participants38,144 healthy blood donors donated in Wuhan, Shenzhen and Shijiazhuang were enrolled, who were all met the criteria for blood donation during the COVID-19 pandemic in China. Main outcome measuresSpecific antibodies against SARS-CoV-2 including total antibody (TAb), IgG antibody against receptor-binding domain of spike protein (IgG-RBD) and nucleoprotein (IgG-N), and IgM. Pseudotype lentivirus-based neutralization test was performed on all TAb-positive samples. In addition, anonymous personal demographic information, including gender, age, ethnicity, occupation and educational level, and blood type were collected. ResultsA total of 519 samples from 410 donors were confirmed by neutralization tests. The SARS-CoV-2 seroprevalence among blood donors was 2.29% (407/17,794, 95%CI 2.08% to 2.52%) in Wuhan, 0.029% (2/6,810, 95%CI 0.0081% to 0.11%) in Shenzhen, and 0.0074% (1/13,540, 95%CI 0.0013% to 0.042%) in Shijiazhuang, respectively. The earliest emergence of SARS-CoV-2 seropositivity in blood donors was identified on January 20, 2020 in Wuhan. The weekly prevalence of SARS-CoV-2 antibodies in Wuhans blood donors changed dynamically and were 0.08% (95%CI 0.02% to 0.28%) during January 15 to 22 (before city lockdown), 3.08% (95%CI 2.67% to 3.55%) during January 23 to April 7 (city quarantine period) and 2.33% (95%CI 2.06% to 2.63%) during April 8 to 30 (after lockdown easing). Female and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among donors in Wuhan. ConclusionsThe prevalence of antibodies to SARS-CoV-2 among blood donors in China was low, even in Wuhan city. According to our data, the earliest emergence of SARS-CoV-2 in Wuhans donors should not earlier than January, 2020. As most of the population of China remained uninfected during the early wave of COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.
Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2020 Document Type: Preprint
Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2020 Document Type: Preprint