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Impaired cellular immunity to SARS-CoV-2 in severe COVID-19 patients
Ling Ni; Meng-Li Cheng; Hui Zhao; Yu Feng; Jingyuan Liu; Fang Ye; Qing Ye; Gengzhen Zhu; Xiaoli Li; Pengzhi Wang; Jing Shao; Yong-qiang Deng; Peng Wei; Fang Chen; Cheng-feng Qin; Guoqing Wang; Fan Li; Hui Zeng; Chen Dong.
  • Ling Ni; Institute for Immunology and School of Medicine,Tsinghua University
  • Meng-Li Cheng; College of Basic Medical Science, Jilin University
  • Hui Zhao; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences
  • Yu Feng; Institute for Immunology and School of Medicine, Tsinghua University
  • Jingyuan Liu; Beijing Ditan Hospital, Capital Medical University, and Beijing Key Laboratory of Emerging Infectious Diseases,
  • Fang Ye; Department of Hematology, Chui Yang Liu Hospital affiliated to Tsinghua University
  • Qing Ye; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences,
  • Gengzhen Zhu; Institute for Immunology and School of Medicine, Tsinghua University
  • Xiaoli Li; Institute for Immunology and School of Medicine, Tsinghua University
  • Pengzhi Wang; Institute for Immunology and School of Medicine, Tsinghua University
  • Jing Shao; Institute for Immunology and School of Medicine, Tsinghua University
  • Yong-qiang Deng; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences
  • Peng Wei; Institute for Immunology and School of Medicine, Tsinghua University
  • Fang Chen; Department of Cardiology, Chui Yang Liu Hospital affiliated to Tsinghua University
  • Cheng-feng Qin; Department of Virology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences
  • Guoqing Wang; College of Basic Medical Science, Jilin University
  • Fan Li; College of Basic Medical Science, Jilin University
  • Hui Zeng; Beijing Ditan Hospital, Capital Medical University, and Beijing Key Laboratory of Emerging Infectious Diseases
  • Chen Dong; Institute for Immunology and School of Medicine, Tsinghua University
Preprint in English | medRxiv | ID: ppmedrxiv-20171371
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ABSTRACT
The World Health Organization has declared SARS-CoV-2 virus outbreak a world-wide pandemic. Individuals infected by the virus exhibited different degrees of symptoms, the basis of which remains largely unclear. Currently, though convalescent individuals have been shown with both cellular and humoral immune responses, there is very limited understanding on the immune responses, especially adaptive immune responses, in patients with severe COVID-19. Here, we examined 10 blood samples from COVID-19 patients with acute respiratory distress syndrome (ARDS). The majority of them (70%) mounted SARS-CoV-2-specific humoral immunity with production of neutralizing antibodies. However, compared to healthy controls, the percentages and absolute numbers of both NK cells and CD8+ T cells were significantly reduced, accompanied with decreased IFN{gamma} expression in CD4+ T cells in peripheral blood from severe patients. Most notably, we failed in detecting SARS-CoV-2-specific IFN{gamma} production by peripheral blood lymphocytes from these patients. Our work thus indicates that COVID-19 patients with severe symptoms are associated with defective cellular immunity, which not only provides insights on understanding the pathogenesis of COVID-19, but also has implications in developing an effective vaccine to SARS-CoV-2.
Full text: Available Collection: Preprints Database: medRxiv Topics: Vaccines Language: English Year: 2020 Document Type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Topics: Vaccines Language: English Year: 2020 Document Type: Preprint