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COVID-19 and Multisystem Inflammatory Syndrome in Latin American children: a multinational study
Omar Yassef Antunez-Montes; Maria Isabel Escamilla; Augusto Flavio Figueroa-Uribe; Erick Arteaga-Menchaca; Manuel Lavariega-Sarachaga; Perla Salcedo-Lozada; Priscilla Melchior; Rodrigo Berea de Oliveira; Juan Carlos Tirado Caballero; Hernando Pinzon Redondo; Laura Vanessa Montes Fontalvo; Roger Hernandez; Carolin Chavez; Francisco Eduardo Campos; Fadia Uribe; Olguita del Aguila; JORGE ALBERTO RIOS AIDA; Andrea Parra Buitrago; Lina Maria Betancur Londono; Leon Felipe Mendoza Vega; Carolina Almeida Hernandez; Michela Sali; JULIAN HIGUITA PALACIO; Jessica Gomez-Vargas; Adriana Yock Corrales; Danilo Buonsenso.
  • Omar Yassef Antunez-Montes; Instituto Latinoamericano de Ecografia en Medicina, Ciudad de Mexico, Mexico.
  • Maria Isabel Escamilla; Fundacion Neumologica Colombiana, Bogota, Colombia.
  • Augusto Flavio Figueroa-Uribe; Hospital Pediatrico Peralvillo. Secretaria de salud, Ciudad de Mexico, Mexico.
  • Erick Arteaga-Menchaca; Hospital General Regional 200. Instituto Mexicano del Seguro Social, Estado de Mexico, Mexico.
  • Manuel Lavariega-Sarachaga; Grupo Home Health Medical, Ciudad de Mexico, Mexico.
  • Perla Salcedo-Lozada; Hospital General de Ecatepec Las Americas Estado de Mexico, Mexico.
  • Priscilla Melchior; Sao Luiz Hospital, Sao Paulo
  • Rodrigo Berea de Oliveira; Sao Luiz Hospital, Sao Paulo
  • Juan Carlos Tirado Caballero; JAS Medica/Plus Medica; Peru
  • Hernando Pinzon Redondo; Hospital Infantil Napoleon Franco Pareja, Botota, Colombia
  • Laura Vanessa Montes Fontalvo; Hospital Infantil Napoleon Franco Pareja, Botota, Colombia
  • Roger Hernandez; Peruvian University Cayetano Heredia, Lima, Peru
  • Carolin Chavez; Unidad de Investigacion de Pediatria, Hospital Cayetano Heredia, Lima, Peru
  • Francisco Eduardo Campos; Unidad de Infectologia Pediatric; Hospital San Bartolome
  • Fadia Uribe; Hospital San Bartolome, Lima. Peru.
  • Olguita del Aguila; Unidad de Infectologia Pediatrica; Hospital Nacional Edgardo Rebagliati Martins. Lima - Peru.
  • JORGE ALBERTO RIOS AIDA; Plus Medica, Lima, Peru
  • Andrea Parra Buitrago; Hospital Pablo Tobon Uribe. Medellin; Colombia
  • Lina Maria Betancur Londono; Hospital Pablo Tobon Uribe. Medellin; Colombia.
  • Leon Felipe Mendoza Vega; Jefe servicio de medicina critica Hospital Infantil de Tlaxcala
  • Carolina Almeida Hernandez; Jefatura de pediatria. Hospital general Las Americas; Estado de Mexico, Mexico
  • Michela Sali; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
  • JULIAN HIGUITA PALACIO; Pediatra, Coordinador Servicio de Urgencias Unidad Funcional Materno Infantil , Medellin, Colombia
  • Jessica Gomez-Vargas; Servicio de Emergencias, Hospital Nacional de Ninos Dr. Carlos Saenz Herrera.
  • Adriana Yock Corrales; Servicio de Emergencias, Hospital Nacional de Ninos Dr. Carlos Saenz Herrera.
  • Danilo Buonsenso; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Preprint in English | medRxiv | ID: ppmedrxiv-20184242
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ABSTRACT
BackgroundTo date, there are no comprehensive data on pediatric COVID-19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome (MIS-C) in Latin American children, in order to appropriately plan and allocate resources to face the pandemic on a local and International lever MethodsAmbispective multicentre cohort study from five Latin American countries. Children aged 18 years or younger with microbiologically confirmed SARS-CoV-2 infection were included. Findings409 children were included, with a median age of 53.0 years (IQR 0.6-9.0). Of these, 95 191 (23.2%) were diagnosed with MIS-C. 191 (46.7%) children were admitted to hospital and 52 (12.7%) required admission to a Pediatric Intensive Care Unite (PICU). 92 (22.5%) patients required oxygen support 8 (2%) were started on continuous positive airway pressure (CPAP) and 29 (7%) on mechanical ventilation. 35 (8.5%) patients required inotropic support. The following factors were associated with PICU admission pre-existing medical condition (P < 0.0001), immunodeficiency (P = 0.01), lower respiratory tract infection (P< 0.0001), gastrointestinal symptoms (P = 0.006), radiological changes suggestive of pneumonia and acute respiratory distress syndrome (P< 0.0001), low socioeconomic conditions (P 0.009). ConclusionsThis study shows a generally more severe form of COVID-19 and a high number of MIS-C in Latin American children, compared with studies from China, Europe and North America, and support current evidence of a more severe disease in Latin/Hyspanic children or in people of lower socioeconomic level. The findings highlight an urgent need of more data of COVID-19 in South America.
Full text: Available Collection: Preprints Database: medRxiv Type of study: Observational study / Risk factors Language: English Year: 2020 Document Type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Type of study: Observational study / Risk factors Language: English Year: 2020 Document Type: Preprint