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Characteristics of changes in circulating markers of alveolar epithelial and endothelial injury in acute respiratory distress syndrome with COVID-19
Kentaro Tojo; Natsuhiro Yamamoto; Takahiro Mihara; Miyo Abe; Takahisa Goto.
  • Kentaro Tojo; Department of Anesthesiology and Critical Care Medicine, Yokohama City University School of Medicine
  • Natsuhiro Yamamoto; Department of Anesthesiology and Critical Care Medicine, Yokohama City University School of Medicine
  • Takahiro Mihara; Department of Health Data Science, Yokohama City University Graduate School of Data Science
  • Miyo Abe; Department of Anesthesiology and Critical Care Medicine, Yokohama City University School of Medicine
  • Takahisa Goto; Department of Anesthesiology and Critical Care Medicine, Yokohama City University School of Medicine
Preprint in English | medRxiv | ID: ppmedrxiv-21249528
ABSTRACT
The time course and specific contributions of alveolar epithelial and endothelial injury to the pathogenesis of acute respiratory distress syndrome (ARDS) with coronavirus disease (COVID-19) remain unclear. Here, we evaluated the characteristics of circulating markers of alveolar epithelial and endothelial injury in serum samples from eleven ARDS patients and ten non-ARDS patients, all with COVID-19. Our results indicates that the alveolar epithelial injury at the very early disease stage and the endothelial injury which continues to exacerbate during the later disease stage seem to be the hallmarks of ARDS with COVID-19.
Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2021 Document Type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2021 Document Type: Preprint