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Influence of sex on disease severity in children with COVID-19 and Multisystem Inflammatory Syndrome in Latin America
Martin Brizuela; Jacopo Lenzi; Rolando Ulloa Gutierrez; Omar Yassef; Jrge Alberto Rios Aida; Olguita del Aguila; Erick arteaga; Francisco Campos; Fadia Uribe; Andrea Parra; Lina Betancur; Jessica Gomez-Vargas; Adriana Yock; danilo buonsenso.
  • Martin Brizuela; Pediatric Infectious Disease, Hospital isidoro Iriarte, Quilmes, Buenos Aires, Argentina
  • Jacopo Lenzi; Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy
  • Rolando Ulloa Gutierrez; Infectious Disease Department. Hospital Nacional de Ninos "Dr. Carlos Saenz Herrera", CCSS, San Jose, Costa Rica.
  • Omar Yassef; Departamento de Docencia e Investigacion, Instituto Latinoamericano de Ecografia en Medicina (ILEM), Ciudad de Mexico, Mexico
  • Jrge Alberto Rios Aida; CLINICA JAS MEDICA, Lima, Peru
  • Olguita del Aguila; Unidad de Infectologia Pediatrica del Hospital Nacional Edgardo Rebagliati Martins-Lima-Peru.
  • Erick arteaga; Hospital General Regional 200 IMSS, Mexico
  • Francisco Campos; Hospital Madre Nino San Bartolome, Lima, Peru
  • Fadia Uribe; Hospital Madre Nino San Bartolome, Lima, Peru
  • Andrea Parra; Hospital Pablo Tobon Uribe Medellin, Colombia
  • Lina Betancur; Fundacion Neumologica Colombiana,Bogota, Colombia
  • Jessica Gomez-Vargas; Pediatric Emergency Department, Hospital Nacional de Ninos "Dr. Carlos Saenz Herrera", CCSS, San Jose, Costa Rica.
  • Adriana Yock; Pediatric Emergency Department, Hospital Nacional de Ninos "Dr. Carlos Saenz Herrera", CCSS, San Jose, Costa Rica.
  • danilo buonsenso; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy
Preprint in English | medRxiv | ID: ppmedrxiv-21251212
ABSTRACT
Data from adult studies how that COVID-19 is more severe in men than women. However, no data are available for the pediatric population. For this reason, we performed this study aiming to understand if sex influenced disease severity and outcomes in a large cohort of latin-american children with COVID-19 and Multisystem Inflammatory Syndrome (MIS-C). We found that a higher percentage of male children developed MIS-C (8.9% vs 5% in females) and died (1.2% and 0.4% in females), although on multivariate adjusted analyses the only statistically significant difference was found in need of hospitalization, with females less frequently admitted compared with boys (25.6% vs 35.4%). This data are preliminary and need further independent studies to better assess the role of sex.
Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2021 Document Type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Language: English Year: 2021 Document Type: Preprint