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Immune profile of children with post-acute sequelae of SARS-CoV-2 infection (Long Covid) (preprint)
medrxiv; 2021.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2021.05.07.21256539
ABSTRACT
There is increasing reporting by patients organization and researchers of long covid (or post-acute sequelae of SARS-CoV-2 - PASC), characterized by symptoms such as fatigue, dyspnea, chest pain, cognitive and sleeping disturbances, arthralgia and decline in quality of life. Immune system dysregulation with a hyperinflammatory state, direct viral toxicity, endothelial damage and microvascular injury have been proposed as pathologenic mechanisms. Recently, cohorts of children with PASC have been reported in Italy, Sweden and Russia. However, immunological studies of children with PASC have never been performed. In this study, we documented significant immunologic differences between children that completely recovered from acute infection and those with PASC, providing the first objective laboratory sign of the existence of PASC in children.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Sleep Wake Disorders
/
Chest Pain
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Acute Disease
/
Microvascular Angina
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Arthralgia
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Chronobiology Disorders
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Drug-Related Side Effects and Adverse Reactions
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Dyspnea
/
Fatigue
/
COVID-19
Language:
English
Year:
2021
Document Type:
Preprint
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