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Short-term Outcomes in Children Recovered from Multisystem Inflammatory Syndrome associated with SARS-CoV-2 infection (preprint)
medrxiv; 2021.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2021.06.23.21259292
ABSTRACT
Background:
Multi System Inflammatory Syndrome in children (MIS-C) associated with COVID-19 is a recently recognised potentially life-threatening entity. There is limited data on post MIS-C sequelae.Methods:
21 children fulfilling the WHO criteria for MIS-C were included in our study. Data was collected at baseline and at 12-16 weeks post discharge to look for any persistent sequelae mainly relating to the lungs or heart including coronary arteries.Results:
Fever was the most common presentation found in 18 (85.7%) patients. All had marked hyper-inflammatory state. Low ejection fraction (EF) was found in 10 (47.6%) but none had any coronary artery abnormality. All received corticosteroids while 7 (33.3%) children required additional treatment with intravenous Immunoglobulins. 20 children improved while 1 left against medical advice. At discharge 3 children had impaired left ventricular function. At median 15 weeks follow-up no persistent complications were found. EF had returned to normal and no coronary artery abnormalities were found during repeat echocardiography. Chest radiographs showed no fibrosis and all biochemical parameters had normalized.Conclusion:
The children with MIS-C are extremely sick during the acute stage. Timely and adequate management led to full recovery without any sequelae at a median follow-up of 15 weeks.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Coronary Artery Disease
/
Fibrosis
/
Ventricular Dysfunction, Left
/
Hyper-IgM Immunodeficiency Syndrome, Type 1
/
Cryopyrin-Associated Periodic Syndromes
/
Fever
/
COVID-19
Language:
English
Year:
2021
Document Type:
Preprint
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