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Evaluation of real-life use of Point-Of-Care Rapid Antigen TEsting for SARS-CoV-2 in schools for outbreak control (EPOCRATES)
Ana C. Blanchard; Marc Desforges; Annie-Claude Labbe; Cat Tuong Nguyen; Yves Petit; Dominic Besner; Kate Zinszer; Olivier Seguin; Zineb Laghdir; Kelsey Adams; Marie-Eve Benoit; Genevieve Leduc; Jean Longtin; Ioannis Ragoussis; David L. Buckeridge; Caroline Quach.
  • Ana C. Blanchard; CHU Sainte-Justine, University of Montreal
  • Marc Desforges; CHU Ste-Justine
  • Annie-Claude Labbe; Hopital Maisonneuve-Rosemont
  • Cat Tuong Nguyen; Direction regionale de sante publique de Montreal
  • Yves Petit; Pensionnat du Saint-Nom-de-Marie
  • Dominic Besner; Ecole secondaire Calixa-Lavallee
  • Kate Zinszer; University of Montreal
  • Olivier Seguin; Direction regionale de sante publique de Montreal
  • Zineb Laghdir; CHU Sainte-Justine
  • Kelsey Adams; CHU Sainte-Justine
  • Marie-Eve Benoit; CHU Sainte-Justine
  • Genevieve Leduc; CHU Sainte-Justine
  • Jean Longtin; Centre hospitalier universitaire (CHU) de Quebec
  • Ioannis Ragoussis; McGill University
  • David L. Buckeridge; McGill University
  • Caroline Quach; University of Montreal
Preprint in English | medRxiv | ID: ppmedrxiv-21264960
ABSTRACT
AbstractO_ST_ABSBackgroundC_ST_ABSWe evaluated the use of rapid antigen detection tests (RADT) for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in school settings to determine RADTs performance compared to PCR. MethodsIn this real-world, prospective observational cohort study, high-school students and staff were recruited from two high-schools in Montreal (Canada) and followed from January 25th to June 10th, 2021. Twenty-five percent of asymptomatic participants were tested weekly by RADT (nasal) and PCR (gargle). Class contacts of cases were tested. Symptomatic participants were tested by RADT (nasal) and PCR (nasal and gargle). The number of cases and outbreaks were compared to other high schools in the same area. ResultsOverall, 2,099 students and 286 school staff members consented to participate. The overall RADTs specificity varied from 99.8 to 100%, with a lower sensitivity, varying from 28.6% in asymptomatic to 83.3% in symptomatic participants. Secondary cases were identified in 10 of 35 classes. Returning students to school after a 7-day quarantine, with a negative PCR on D6-7 after exposure, did not lead to subsequent outbreaks. Of cases for whom the source was known, 37 of 57 (72.5%) were secondary to household transmission, 13 (25%) to intra-school transmission and one to community contacts between students in the same school. ConclusionRADT did not perform well as a screening tool in asymptomatic individuals. Reinforcing policies for symptom screening when entering schools and testing symptomatic individuals with RADT on the spot may avoid subsequent significant exposures in class. Table of Contents SummaryRapid antigen tests were compared to standard PCR to diagnose SARS-CoV-2 infections in high-school students. They performed better in symptomatic individuals. Whats Known on This SubjectRapid antigen detection tests (RADT) are often used to diagnose respiratory pathogens at the point-of-care. Their performance characteristics vary, but they usually have high specificity and moderate sensitivity compared with PCR. What This Study AddsRADT sensitivity ranged from 28.6% in asymptomatic individuals to 83.3% in symptomatic individuals. Return to school after 7 days of quarantine was safe in exposed students. Secondary cases were identified in 28% of classes with an index case.
Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Language: English Year: 2021 Document Type: Preprint