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Vaccine-induced humoral and cellular immunity against SARS-CoV-2 at 6 months post BNT162b2 vaccination
Hideaki Kato; Kei Miyakawa; Norihisa Ohtake; Yutaro Yamaoka; Satoshi Yajima; Etsuko Yamazaki; Tomoko Shimada; Atsushi Goto; Hideaki Nakajima; Akihide Ryo.
  • Hideaki Kato; Infection Prevention and Control Department, Yokohama City University Hospital, Yokohama, Japan
  • Kei Miyakawa; Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan
  • Norihisa Ohtake; Bioscience Division, Research and Development Department, Tosoh Corporation, Tokyo Research Center, Kanagawa, Japan
  • Yutaro Yamaoka; Life Science Laboratory, Technology and Development Division, Kanto Chemical Co, Inc., Isehara, Japan
  • Satoshi Yajima; Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan
  • Etsuko Yamazaki; Clinical Laboratory Department, Yokohama City University Hospital, Yokohama, Japan
  • Tomoko Shimada; Nursing Department, Yokohama City University Hospital, Yokohama, Japan
  • Atsushi Goto; Department of Health Data Science, Yokohama City University Graduate School of Data Science, Yokohama, Japan
  • Hideaki Nakajima; Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Japan
  • Akihide Ryo; Department of Microbiology, Yokohama City University School of Medicine, Yokohama, Japan
Preprint in English | medRxiv | ID: ppmedrxiv-21265693
ABSTRACT
To evaluate vaccine-induced humoral and cell-mediated immunity at 6 months post BNT162b2 vaccination, immunoglobulin G against SARS-CoV-2 spike protein (SP IgG), 50% neutralizing antibody (NT50), and spot-forming cell (SFC) counts were evaluated by interferon-{gamma} releasing ELISpot assay of 98 healthy subjects (median age, 43 years). The geometric mean titers of SP IgG and NT50 decreased from 95.2 (95% confidence interval (CI) 79.8-113.4) to 5.7 (95% CI 4.9-6.7) and from 680.4 (588.0-787.2) to 130.4 (95% CI 104.2-163.1), respectively, at 3 weeks and 6 months after the vaccination. SP IgG titer was negatively correlated with age and alcohol consumption. Spot-forming cell counts at 6 months did not correlate with age, gender, and other parameters of the patients. SP IgG, NT50, and SFC titers were elevated in the breakthrough infected subjects. Although the levels of vaccine-induced antibodies dramatically declined at 6 months after vaccination, a certain degree of cellular immunity was observed irrespective of the age.
Full text: Available Collection: Preprints Database: medRxiv Topics: Vaccines Language: English Year: 2021 Document Type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Topics: Vaccines Language: English Year: 2021 Document Type: Preprint