Your browser doesn't support javascript.
Analysis of humoral immunity against emerging SARS-CoV-2 variants: a population-based prevalence study in Yokohama, Japan
Atsushi Goto; Kei Miyakawa; Izumi Nakayama; Susumu Yagome; Juan Xu; Makoto Kaneko; Norihisa Ohtake; Hideaki Kato; Akihide Ryo.
  • Atsushi Goto; Yokohama City University
  • Kei Miyakawa; Yokohama City University
  • Izumi Nakayama; Yokohama City University
  • Susumu Yagome; Yokohama City University
  • Juan Xu; Yokohama City University
  • Makoto Kaneko; Yokohama City University
  • Norihisa Ohtake; Tosoh Corporation
  • Hideaki Kato; Yokohama City University
  • Akihide Ryo; Yokohama City University School of Medicine
Preprint in English | medRxiv | ID: ppmedrxiv-22272766
ABSTRACT
BackgroundLittle is known about the population prevalence of antibodies against emerging immune escape variants of SARS-CoV-2. MethodsA population-based prevalence study was conducted in Yokohama City, the most populous municipality of Japan. Quantitative measurements of immunoglobulin G against SARS-CoV-2 spike protein (SP-IgG) and qualitative measurements of neutralization antibodies against the Omicron BA.1 and BA.2 variants were performed. ResultsOf 6,000 randomly selected residents aged 20-74, 1,277 participated in the study during a period from January 30 to February 28, 2022. Of them, 3% had prior diagnosis of COVID-19, 96% received at least two-doses of SARS-CoV-2 vaccines, and 94% were positive for SP-IgG. The positive rates of neutralizing antibodies were 28% to Omicron BA.1 and BA.2 variants in a random sample of 10% of participants (n=123) and 100% to BA.1 and BA.2 among participants who received the third vaccination at least 7 days before (n=66). ConclusionsIn this population-based prevalence study in Japan, most had SP-IgG antibodies but the overall neutralizing antibody positive rate was 28% against the Omicron BA.1 and BA.2 variants. The population-level insufficient humoral immunity against the Omicron variants may explain the outbreak of COVID-19 during this period in Japan.
Full text: Available Collection: Preprints Database: medRxiv Type of study: Prevalence study / Qualitative research / Randomized controlled trials / Risk factors Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Preprint

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Collection: Preprints Database: medRxiv Type of study: Prevalence study / Qualitative research / Randomized controlled trials / Risk factors Topics: Vaccines / Variants Language: English Year: 2022 Document Type: Preprint