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Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses (preprint)
biorxiv; 2020.
Preprint
in English
| bioRxiv | ID: ppzbmed-10.1101.2020.03.24.005900
ABSTRACT
Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-{beta} (TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever virus and dengue virus-2 replication. Remarkably, we found that TOP3B is required for efficient replication of all positive-sense-single stranded RNA viruses tested, including SARS-CoV-2. While there are no drugs that specifically inhibit this topoisomerase, we posit that TOP3B is an attractive anti-viral target.
Full text:
Available
Collection:
Preprints
Database:
bioRxiv
Main subject:
Yellow Fever
Language:
English
Year:
2020
Document Type:
Preprint
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