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Single-cell RNA-seq reveals profound monocyte changes in Paediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-CoV-2 infection (PIMS-TS) (preprint)
medrxiv; 2020.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2020.08.06.20164848
ABSTRACT
Paediatric inflammatory multisystem inflammatory syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS) is a new disease with overlapping features of Kawasaki disease (KD) and toxic shock syndrome. Unbiased single cell RNA sequencing analysis of peripheral blood mononuclear cells from PIMS-TS and KD patients shows monocytes are the main source of pro-inflammatory cytokines and large changes in the frequency of classical, intermediate and non-classical monocytes occur in both diseases.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Shock, Septic
/
Cryopyrin-Associated Periodic Syndromes
/
COVID-19
/
Mucocutaneous Lymph Node Syndrome
Language:
English
Year:
2020
Document Type:
Preprint
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