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A repurposed, blood gene signature is associated with poor outcomes in SARS-CoV-2 (preprint)
biorxiv; 2020.
Preprint
in English
| bioRxiv | ID: ppzbmed-10.1101.2020.11.21.392670
ABSTRACT
Poor outcomes after SARS-CoV-2 infection are difficult to predict. Survivors may develop pulmonary fibrosis. We previously identified a 52-gene signature in peripheral blood, predictive of mortality in Idiopathic Pulmonary Fibrosis. In this study, we analyzed this signature in SARS-CoV-2 infected individuals and identified genomic risk profiles with significant differences in outcomes. Analysis of single cell expression data shows that monocytes, red blood cells, neutrophils and dendritic cells are the cellular source of the high risk gene signature.
Full text:
Available
Collection:
Preprints
Database:
bioRxiv
Main subject:
Pulmonary Fibrosis
/
Severe Acute Respiratory Syndrome
/
Idiopathic Pulmonary Fibrosis
/
COVID-19
Language:
English
Year:
2020
Document Type:
Preprint
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