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Functional and microstructural brain abnormalities, fatigue, and cognitive dysfunction after mild COVID-19 (preprint)
medrxiv; 2021.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2021.03.20.21253414
ABSTRACT
Although post-acute cognitive dysfunction and neuroimaging abnormalities have been reported after hospital discharge in patients recovered from COVID-19, little is known about persistent, long-term alterations in people without hospitalization. We conducted a cross-sectional study of 87 non-hospitalized recovered individuals 54 days after the laboratory confirmation of COVID-19. We performed structured interviews, neurological examination, 3T-MRI scans with diffusion tensor images (DTI) and functional resting-state images (fMRI). Also, we investigated fatigue, anxiety, depression, somnolence, language, memory, and cognitive flexibility, using validated instruments. Individuals self-reported a high frequency of headache (40%) and memory difficulties (33%). The quantitative analyses confirmed symptoms of fatigue (68%), excessive somnolence (35%), anxiety (29%), impaired cognitive flexibility (40%) and language impairment (33%). There were widespread cerebral white matter alterations (mainly characterized by increased fractional anisotropy), which correlated with abnormal attention and cognitive flexibility. The resting-state fMRI networks analysis showed severely disrupted brain hyperconnectivity and loss of resting-state networks specificity.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Anxiety Disorders
/
Brain Diseases
/
Cognition Disorders
/
Depressive Disorder
/
Mobility Limitation
/
Fatigue
/
COVID-19
/
Headache
/
Disorders of Excessive Somnolence
/
Language Disorders
Language:
English
Year:
2021
Document Type:
Preprint
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