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Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET (preprint)
medrxiv; 2022.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2022.06.02.22275916
ABSTRACT
Summary A significant number of COVID-19 patients develop ‘long COVID’, a condition defined by long-lasting debilitating, often neurological, symptoms. The pathophysiology of long COVID is unknown. Here we present in-vivo evidence of widespread neuroinflammation in long COVID, using a quantitative assessment, [ 18 F]DPA-714 PET, in two long COVID patients. We reanalyzed historical data from three matched healthy control subjects, for comparison purposes. Both patients with long COVID had widespread increases in [ 18 F]DPA-714 binding throughout the brain. Quantitative measures of binding (BP ND values) were increased on average by 121% and 76%, respectively. This implicates profound neuroinflammation in the pathophysiology of long COVID.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Long QT Syndrome
/
COVID-19
Language:
English
Year:
2022
Document Type:
Preprint
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