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Human Amylin in the Presence of SARS-COV-2 Protein Fragments (preprint)
biorxiv; 2023.
Preprint
in English
| bioRxiv | ID: ppzbmed-10.1101.2023.01.30.526275
ABSTRACT
Covid-19 can lead to the onset of type-II diabetes which is associated with aggregation of islet amyloid polypeptides, also called amylin. Using molecular dynamics simulations, we investigate how the equilibrium, between amylin monomers in its functional form and fibrils associated with diabetes, is altered in presence of SARS-COV-2 protein fragments. For this purpose, we study the interaction between the fragment SFYVYSRVK of the Envelope protein or the fragment FKNIDGYFKI of the Spike protein with the monomer and two amylin fibril models. Our results are compared with earlier work studying such interactions for two different proteins.
Full text:
Available
Collection:
Preprints
Database:
bioRxiv
Main subject:
Diabetes Mellitus
/
Diabetes Mellitus, Type 2
/
COVID-19
Language:
English
Year:
2023
Document Type:
Preprint
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