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Pulmonary sequelae at six months in children with SARS-CoV-2 infection: A Single-Centre Study (preprint)
medrxiv; 2023.
Preprint in English | medRxiv | ID: ppzbmed-10.1101.2023.03.10.23286644
ABSTRACT

Objective:

Pulmonary sequelae post SARS - CoV-2 infection have been reported in adults; however, there is scant literature regarding pulmonary dysfunction following SARS-CoV-2 infection in children. We studied the long term pulmonary sequelae in children who had SARS-CoV-2 infection.

Methods:

This single center descriptive study conducted in a public sector tertiary care hospital in Northern India, from June, 2020 to October, 2021. We enrolled children aged 7-18 years admitted with SARS-CoV-2 infection and followed them up for 6 months. A detailed interval history was taken and pulmonary function tests were performed after 6 months, using a spirometer. A convenience sample of 40 children was enrolled. There were 21 males and the median (IQR) age was 13 (10.75, 17) years.

Results:

Thirty percent of children (n=12) had pulmonary function abnormalities, which was of restrictive pattern in all. Children who were underweight had higher odds of developing pulmonary dysfunction following SARS-CoV-2 infection [OR (95% CI) 5.13 (1.19, 22.11); P=0.028]. There were no significant association with age, sex, severity of initial infection and oxygen requirement during the initial infection. Three children had persistence of dyspnea during follow up.

Conclusion:

This study is the one of the first Indian studies regarding the pulmonary sequelae in children. A possibility of long term sequelae should be considered in children with history of SARS-CoV-2, presenting with suggestive complaints.
Subject(s)

Full text: Available Collection: Preprints Database: medRxiv Main subject: Dyspnea / Lung Injury / COVID-19 / Sleep Initiation and Maintenance Disorders / Lung Diseases Language: English Year: 2023 Document Type: Preprint

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Full text: Available Collection: Preprints Database: medRxiv Main subject: Dyspnea / Lung Injury / COVID-19 / Sleep Initiation and Maintenance Disorders / Lung Diseases Language: English Year: 2023 Document Type: Preprint