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Vagus nerve inflammation contributes to dysautonomia in COVID-19 (preprint)
medrxiv; 2023.
Preprint
in English
| medRxiv | ID: ppzbmed-10.1101.2023.06.14.23291320
ABSTRACT
Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes remain unknown. Here, we show that SARS-CoV-2 is detectable in postmortem vagus nerve specimen together with inflammatory cell infiltration derived primarily from monocytes. This is associated with a decreased respiratory rate in non-survivors of critical COVID-19. Our data suggest that SARS-CoV-2 induces vagus nerve inflammation followed by autonomic dysfunction.
Full text:
Available
Collection:
Preprints
Database:
medRxiv
Main subject:
Vagus Nerve Diseases
/
Primary Dysautonomias
/
COVID-19
/
Inflammation
Language:
English
Year:
2023
Document Type:
Preprint
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