Creatinine levels on admission are main modulators of COVID-19 severity (preprint)

ABSTRACT

Background: The COVID-19 pandemic claimed millions of lives worldwide without clear signs of abating. There have been tremendous interests in understanding the etiology of the disease particularly in what makes it fatal in certain patients. Methods: This study investigated 819 COVID-19 patients admitted to the COVID-19 ward at a tertiary care center in Lebanon and evaluated their vital signs and biomarkers while probing for two main outcomes: intubation and fatality. Results: Correlation analysis of various comorbidities revealed that hypertension, diabetes, being overweight, kidney disease, cardiovascular disease, autoimmune disease, and gender are independent risk factors for both intubation and fatality. Shortness of breath, age and being overweight correlated with intubation while fatality correlated with shortness of breath in our group of patients. Elevated level of serum creatinine was the highest correlating factor with fatality, while both white blood count and serum glutamic-oxaloacetic transaminase levels emerged as independent risk factors for intubation. Conclusions: Collectively our data show that high creatinine levels are significantly associated with fatality in our COVID-19 study patients, underscoring the importance of kidney function as a main modulator of SARS-CoV-2 morbidity and favor a careful management of patients with elevated creatinine levels on admission.