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An Analysis on the Clinical Features of MHD Patients with Coronavirus Disease 2019: A Single Center Study (preprint)
researchsquare; 2020.
Preprint in English | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-18043.v1
ABSTRACT

Background:

In this study, we aimed to find out the features of the maintenance hemodialysis (MHD) patients infected with Coronavirus Disease 2019 (COVID-19) in the Blood Purification Center of Wuhan No.1 Hospital, Hubei Province, China, and provide evidences for clinical treatment.

Methods:

We collected the data of all the MHD patients in this hemodialysis center by February 20, 2020, including those infected with COVID-19. These patients were divided into three groups the control group (537 cases), confirmed group (66 cases) and suspected group (24 cases). We compared the relevant data of the three groups and analyzed the factors that may affect the possibility of catching COVID-19.

Results:

1. By February 20, 2020, there were 627 MHD patients in the Hemodialysis Center of Wuhan No.1 Hospital. The prevalence rate of the COVID-19 was 14.35% (90/627, including 66 confirmed cases and 24 suspected cases); the fatality rate 13.33% (12/90, including 12 death cases); the mortality rate 1.91% (12/627).2. The comparison between the three groups revealed the following

results:

weekly hemodialysis duration (WHD), ultrafiltration volume (UFV) and ultrafiltration rate (UFR) of the confirmed group were obviously lower than those of the control and suspected groups (P<0.05); the neutrophil ratio (N%), neutrophil (N#), monocyte (M#) and total carbon dioxide (TCO2) were significantly higher than those of the control group while the lymphocyte ratio (L%) was much lower (P<0.05).3. The lung CT scans found three common features bilateral abnormalities (81.54%), multiple abnormalities (84.62%) and patchy opacity (61.54%).4. The binary logstic regression analysis showed that diabetes (OR=5.404,95% CI 1.950~14.976, P=0.001) and hypertension (OR=3.099,95% CI 1.380~6.963, P=0.006) are independent risk factors for MHD patients to be infected with COVID-19; WHD (OR=0.846,95% CI 0.737~0.970, P=0.017), UFR (OR=0.012,95% CI 0.002~0.058, P<0.001) and serum ferritin (SF, OR=0.823,95% CI 0.748~0.906, P<0.001) are independent protective factors.

Conclusion:

MHD patients with diabetes or hypertension are more likely to be infected with COVID-19. In clinical treatment, hemodialysis duration, UFR and SF levels should be controlled appropriately to reduce the risk of infection.
Subject(s)

Full text: Available Collection: Preprints Database: PREPRINT-RESEARCHSQUARE Main subject: Abnormalities, Multiple / Hemophilia B / Death / Diabetes Mellitus / COVID-19 / Hypertension / Sleep Initiation and Maintenance Disorders Language: English Year: 2020 Document Type: Preprint

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Full text: Available Collection: Preprints Database: PREPRINT-RESEARCHSQUARE Main subject: Abnormalities, Multiple / Hemophilia B / Death / Diabetes Mellitus / COVID-19 / Hypertension / Sleep Initiation and Maintenance Disorders Language: English Year: 2020 Document Type: Preprint