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Consensus insertion/deletions and amino acid variations of all coding and noncoding regions of the SARS-CoV-2 Omicron clades, including the XBB and BQ.1 lineages (preprint)
researchsquare; 2022.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2400971.v1
ABSTRACT
The currently dominant Omicron variant of the severe acute respiratory syndrome 2 (SARS-CoV-2) has swiftly diverged into clades. To predict the probable impact of clades, the consensus insertions/deletions (indels) and amino acid substitutions of the whole genome of clades were compared with original SARS-CoV-2. The indels and polymorphic amino acids were clade specific or shared among clades. The 21K clade has unique indels and substitutions, which probably represents reverted indels/substitutions. Three observed probable indirect evidences of SARS-CoV-2 attenuation in Omicron clades were deletion in Nucleocapsid, deletion in 3’-untranslated region, and truncation in open reading frame 8.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Main subject:
Respiratory Insufficiency
Language:
English
Year:
2022
Document Type:
Preprint
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