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Effect of High-Dose Vitamin D on Inflammatory Status of ICU Patients with COVID-19; a Double-Blind, Parallel Randomized Clinical Trial (preprint)
researchsquare; 2023.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2558506.v1
ABSTRACT
Background:
Vitamin D can stall hyper-inflammatory responses, and there are mechanistic reasons for the positive effects of vitamin D in COVID-19 patients.Objectives:
Therefore, this study aimed to evaluate the effect of a single high dose of vitamin D on inflammatory markers in critical patients with COVID-19. Design and patients A single center, double-blind, randomized clinical trial was conducted on 61 patients with COVID-19 admitted to the intensive care units. The intervention and placebo groups received a dose of 300,000 IU vitamin D intramuscularly and identical placebo respectively. Patients were followed up for one week. Lactate Dehydrogenase (LDH) (IU/ml), C-reactive protein (CRP) (mg/L), interleukin-6 (IL-6) (Pg/L), lymphocyte, neutrophil, and neutrophil/lymphocyte (N/L) ratios were checked at the beginning and 7 th day of the study. Keyresults:
A total of 44 patients with COVID-19 have completed this trial with vitamin D insufficiency in the baseline. The lymphocyte level increased while LDH (IU/ml), neutrophil level, and N/L ratio decreased after intervention with a high vitamin D dose, which was insignificant. The CRP (mg/L) and IL-6 (Pg/L) were significantly reduced after high-dose vitamin D intervention.Conclusions:
Based on the results, the effect of high doses of vitamin D on inflammatory indices was significant in patients with COVID-19 hospitalized in the ICU.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Main subject:
Addison Disease
/
COVID-19
Language:
English
Year:
2023
Document Type:
Preprint
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