This article is a Preprint
Preprints are preliminary research reports that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Preprints posted online allow authors to receive rapid feedback and the entire scientific community can appraise the work for themselves and respond appropriately. Those comments are posted alongside the preprints for anyone to read them and serve as a post publication assessment.
Sevoflurane sedation in COVID-19 acute respiratory distress syndrome: an observational study with a propensity score matching model (preprint)
researchsquare; 2023.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2586452.v1
ABSTRACT
Background:
Patients that are affected by severe induced respiratory failure (C-ARDS) formCOVID-19, frequently need deep sedation in order to perform adequate ventilator support. Volatile anesthetics (VAs) constitute a convenient alternative to intravenous molecules, allowing to fine-tune the desired level of sedation. Moreover, VAs might have anti-inflammatory and bronchodilatatory effects, which are particularly appropriate for COVID-19 patients.Methods:
In this study, we show the results of a retrospective single-center non-profit observational cohort study. To achieve this, we enrolled patients hospitalized for C-ARDS in the COVID Intensive Care Unit of Hospital Santo Stefano (Prato, Italy) during the period March 2020 - June 2021. A total of 112 patients were enrolled in the study that were all submitted to invasive mechanical ventilation. Participants were divided in two groups i) Group 1 received the VA sevoflurane and, ii) Group 2 were sedated with propofol and remifentanil. A propensity score matching model (PSM) was applied in order match each treated unit with a non-treated unit of similar characteristics between the two groups. The calculation of PSM was performed considering anthropometric data such as age, sex, body mass index (BMI) and comorbidities such as arterial hypertension, chronic obstructive pulmonary disease (COPD), ischemic heart disease, and chronic kidney damage as covariates. Level of sedation (BIS monitoring), respiratory and ventilator parameters, i.e., PaO2/FiO2, pulmonary static compliance and positive end expiratory pressure (PEEP) and biochemical parameters were evaluated at three time-points at the time of the invasive ventilation (T1), after 72 hours (T2) and after 7 days (T3).Results:
56 patients who received inhaled sedation with sevoflurane were matched with 56 participants receiving an intravenous sedation by means of PSM. An adequate level of sedation was obtained in both groups. In the sevoflurane group, an increase of PaO2/FiO2 and of the static compliance was observed while mortality was slightly decreased.Conclusions:
In this work, we demonstrate that deep sedation of invasively ventilated C-ARDS patients can be effectively obtained with sevoflurane. Interestingly, VA sedation with sevoflurane contributed to enhance respiratory mechanics, which has a clear clinical relevance in C-ARDS patients. In terms of pulmonary compliance, results obtained after three days of starting sedation therapy with sevoflurane demonstrated that static compliance was higher in those who received inhaled sedation. At the same timing, PaO2/FiO2 ratio at the same timing was greater in group 1 than in group 2. Further studies deem to confirm the potential of this treatment in a randomized clinical trial.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Language:
English
Year:
2023
Document Type:
Preprint
Similar
MEDLINE
...
LILACS
LIS