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The first case of acute necrotizing encephalopathy associated with coronavirus disease in a child in Asia: a case report and literature review (preprint)
researchsquare; 2023.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2621182.v1
ABSTRACT
Background Acute necrotic encephalopathy(ANE) in children is a very rare complication of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection, which has rarely been reported worldwide. Case presentation A 45-day-old girl was admitted to our hospital with fever and listlessness. A nose swab tested positive for novel coronavirus nucleic acid, and her cerebrospinal fluid was positive for SARS-CoV-2. An early head magnetic resonance imaging (MRI) scan indicated multiple abnormal signals in her bilateral cerebral hemispheres, and encephalitis was diagnosed. Twenty-three days after hospitalization, bilateral cerebral atrophy-like changes were observed by MRI, with multiple softening lesions in the bilateral cerebral hemispheres, accompanied by convulsions. She was admitted to hospital for mechanically-assisted ventilation, and her condition improved after treatment of her symptoms, including anti-epileptic medication, anti-infection drugs, glucocorticoids, and immunoglobulins. Conclusions Acute necrotic encephalopathy associated with novel coronavirus infection in children should be detected and treated as early as possible. Satisfactory short-term efficacy can be obtained, but long-term neurological sequelae often linger.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Main subject:
Atrophy
/
Seizures
/
Brain Diseases
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Coronavirus Infections
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Severe Acute Respiratory Syndrome
/
Encephalitis
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Epilepsy
/
Fever
Language:
English
Year:
2023
Document Type:
Preprint
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