This article is a Preprint
Preprints are preliminary research reports that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Preprints posted online allow authors to receive rapid feedback and the entire scientific community can appraise the work for themselves and respond appropriately. Those comments are posted alongside the preprints for anyone to read them and serve as a post publication assessment.
Knee osteonecrosis after SARS-CoV-2 infection: a systematic case-based review (preprint)
researchsquare; 2023.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2934553.v1
ABSTRACT
Background:
SARS-CoV-2 is the virus responsible for COVID-19. Patients with Covid-19 manifested symptoms mainly related to the respiratory system, but also the musculoskeletal system can be involved. Covid-19 has been described as a possible cause of knee osteonecrosis (ON). We performed a systematic review to investigate the hypothetical correlation between Covid-19 and knee ON.Methods:
Inclusion criteria were all articles reporting cases of knee ON after a diagnosis of SARS-CoV-2 infection. Considering that Covid-19 is an emerging disease, we included all levels of evidence studies.Results:
We finally included 2 case series and 2 case reports. We extracted data regarding demographic and clinical characteristics, details of magnetic resonance imaging (MRI), use of corticosteroids (CCS), temporal correlation between ON and Covid-19, treatment of the lesion and its outcomes. A total of 6 cases of post-Covid knee ON have been described. Knee pain arose on average 8 weeks after the diagnosis of Covid-19. All patients had knee MRI showing osteonecrosis. CCS were used to treat COVID-19-related symptoms in 3 cases. The medial femoral condyle was always involved by ON. Conservative treatment was successful in 4 patients.Conclusions:
It is unclear the correlation between COVID-19 and ON. Probably post Covid-19 osteonecrosis has a multifactorial origin in which factors related to the patient, consequences of Covid-19 and CCS therapy add up to cause a reduction of blood supply and bone vitality until ON is triggered. A greater number of patients is needed to clarify the role of Covid-19 in the etiopathogenesis of knee ON.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Main subject:
Osteonecrosis
/
Pain
/
COVID-19
Language:
English
Year:
2023
Document Type:
Preprint
Similar
MEDLINE
...
LILACS
LIS