This article is a Preprint
Preprints are preliminary research reports that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Preprints posted online allow authors to receive rapid feedback and the entire scientific community can appraise the work for themselves and respond appropriately. Those comments are posted alongside the preprints for anyone to read them and serve as a post publication assessment.
Association between salivary SARS-CoV-2 viral load and acute and late symptoms of COVID-19 in non- hospitalized patients: A cohort study (preprint)
researchsquare; 2023.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-2949163.v1
ABSTRACT
Background The clinical course of COVID-19 can be divided into two phases acute and late.Aims This study evaluated the association between salivary SARS-CoV-2 load and acute and late symptoms of COVID-19 in non-hospitalized patients.Methods This cohort study included 109 participants who tested positive for SARS-CoV-2 in a rapid antigen test (Ethics Committee, 4.434.828). Saliva samples were obtained and acute symptoms were recorded immediately after the diagnosis of COVID-19. Late symptoms were recorded 3 months later. The viral load was estimated based on real-time reverse transcription polymerase chain reaction (qRT-PCR) cycle threshold (Ct). The chi-square and Student t test were used to assess the association between salivary viral load and symptoms (p ≤ 0.05).Results A lower salivary viral load was associated with diarrhea (RR = 0.73, 95% CI = 0.55–0.97, p = 0.04), anosmia (RR = 0.63, 95% CI = 0.47–0.84, p = 0.002), and dysgeusia (RR = 0.69, 95% CI = 0.52–0.91, p = 0.01) in the acute phase of the infection. Regarding late symptoms, a lower viral load remained associated with anosmia (RR = 0.68, 95% CI = 0.51–0.90, p = 0.05) and dysgeusia (RR = 0.59, 95% CI = 0.50–0.70, p = 0.03).Conclusion Lower viral load is a known marker of mild COVID-19. The association of lower viral load with anosmia and dysgeusia in the acute and late phases of the disease and with diarrhea in the acute phase suggests that these symptoms are predictive of mild COVID-19.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Main subject:
Diarrhea
/
Dysgeusia
/
COVID-19
/
Olfaction Disorders
Language:
English
Year:
2023
Document Type:
Preprint
Similar
MEDLINE
...
LILACS
LIS