The Cardiac Injury in Hospitalized Patients with Severe COVID-19 in Wuhan, China (preprint)

ABSTRACT

Background: The Coronavirus disease 2019 (COVID-19) has caused a global pandemic since December 2019, while the date on the relationship between cardiac injury and mortality in patients with COVID-19 is limited.Methods: All consecutive lab-confirmed critically ill COVID-19 patients in intensive care unit of Wuhan Red Cross Hospital from December 30, 2019 to March 18, 2020, were enrolled. Data of patients were collected. The prevalence of cardiac injury and its association with in-hospital mortality was analyzed.Results: Among the 50 ICU patients, 36 patients (72.0%) were complicated with cardiac injury and 14 patients (28.0%) without cardiac injury. Patients with cardiac injury had higher white blood cell counts, values of d-dimer, levels of lactate concentration, APACHE II score and lower PaO2/FiO2 at the time of admission than those without cardiac injury. The in-hospital case fatality ratio was higher in the cardiac injury than non-cardiac injury group (75.0% vs 21.4%;p=0.002).Multivariable-adjusted logistic proportional hazard regression analysis showed that a significantly higher risk of death in patients with cardiac injury than those without cardiac injury (OR, 5.876; 95% CI, 1.039–33.228).Conclusions: Cardiac injury is a common compilation and associated with higher risk of in-hospital death in patients with severe COVID-19.