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Impact of COVID-19 on gamete quality and embryo development in patients with COVID-19 positive undergoing ART (preprint)
researchsquare; 2023.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-3088255.v1
ABSTRACT
BackgroudCOVID-19 was recognized a public health issue and SARS-CoV-2 was assumed to infect human ovary and cross the blood–testis barrier. Method:
To explore the infection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients’ semen and follicular fluid and its potential clinical outcome. Ten female patients with an average age of 30.7±4.11years and eight male patients with an average age of 32.13±4.45 years diagnosed with COVID-19 and their spouses were negative to COVID-19 were included.Results:
None of ten male and 8 female patients with COVID-19 affecting was absence of SARS-CoV-2 RNA in semen and follicular fluid. The sperm parameters, the rates of oocytes maturation, fertilization, cleavage and blastulation between the control and test group was not statistically significant (P>0.05),but the sperm quality, the oocyte maturation and fertilization, the blastulation showed a decline tendency in COVID-19 affected patients.Conclusion:
COVID-19 affection may have an uncertian negative influence on the gamete quality and embryo development. Our new knowledge will help to evaluate the impact of COVID-19 on fertility in virus infected patients.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Main subject:
Ovarian Neoplasms
/
Tumor Virus Infections
/
Coronavirus Infections
/
COVID-19
Language:
English
Year:
2023
Document Type:
Preprint
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