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Necrotising Vasculitis in Covid-19: watch out for bowel perforation (preprint)
researchsquare; 2020.
Preprint in English | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-79258.v1
ABSTRACT

Introduction:

SARS-Cov-2 infection can be asymptomatic, greatly impair respiratory function and, sometimes, affect other organs. Gastro-enteric involvement seems to be not so rare and many patients suffered for abdominal pain, anorexia, nausea and vomiting, diarrhoea or jaundice. Case presentation Here we report a case of a Covid-19 patient who developed a right colon perforation due to a pseudomembranous colitis without Clostridium Difficile toxins finding associated to a necrotising vasculitis. In this patient a PCR test performed on gastric fluid showed SARS-CoV-2 enteric replication.

Discussion:

Necrotizing vasculitis is an anatomopathological typical findings in Covid-19. It has been documented in several organs and tissues. In our case, evident foci of necrotizing vasculitis with intravascular obliteration by fibrin thrombi with macrophagic cells infiltration are anatomopathological findings of a CD toxins free pseudomembranous colitis leading to bowel perforation.

Conclusions:

Bowel perforation due to necrotizing vasculitis leading to pseudomembranous colitis could be a SARS-Cov-2 related clinical finding.
Subject(s)

Full text: Available Collection: Preprints Database: PREPRINT-RESEARCHSQUARE Main subject: Vasculitis / Vomiting / Enterocolitis, Pseudomembranous / Colorectal Neoplasms / Anorexia / Abdominal Pain / Diarrhea / COVID-19 / Jaundice / Nausea Language: English Year: 2020 Document Type: Preprint

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Full text: Available Collection: Preprints Database: PREPRINT-RESEARCHSQUARE Main subject: Vasculitis / Vomiting / Enterocolitis, Pseudomembranous / Colorectal Neoplasms / Anorexia / Abdominal Pain / Diarrhea / COVID-19 / Jaundice / Nausea Language: English Year: 2020 Document Type: Preprint