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Placental maternal vascular malperfusion affecting late fetuses development and multi-organ infection caused by SARS-CoV-2 (preprint)
researchsquare; 2020.
Preprint
in English
| PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-88599.v1
ABSTRACT
Background:
Pregnant women are susceptible to the novel coronavirus (SARS-CoV-2) and the consequences on the fetus are still uncertain. Here, we present a case of a pregnant woman with subclinical hypothyroidism and PAI-1 4G/5G mutation who was infected with SARS-CoV-2 at the end of the third trimester of pregnancy.Methods:
nested PCR were performed to detect the virus, followed by ssDNA sequencing.Results:
transplacental transmission of SARS-CoV-2 can cause placental inflammation, ischemia and neonatal viremia, with complications such as preterm labor and damage to the placental barrier in patients with PAI-1 4G/5G mutation.Conclusion:
we show the possibility of transplacental transmission of SARS-CoV-2 infection during the last weeks of pregnancy.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-RESEARCHSQUARE
Main subject:
Viremia
/
COVID-19
/
Hypothyroidism
/
Inflammation
/
Ischemia
/
Obstetric Labor, Premature
Language:
English
Year:
2020
Document Type:
Preprint
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