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Placental maternal vascular malperfusion affecting late fetuses development and multi-organ infection caused by SARS-CoV-2 (preprint)
researchsquare; 2020.
Preprint in English | PREPRINT-RESEARCHSQUARE | ID: ppzbmed-10.21203.rs.3.rs-88599.v1
ABSTRACT

Background:

Pregnant women are susceptible to the novel coronavirus (SARS-CoV-2) and the consequences on the fetus are still uncertain. Here, we present a case of a pregnant woman with subclinical hypothyroidism and PAI-1 4G/5G mutation who was infected with SARS-CoV-2 at the end of the third trimester of pregnancy.

Methods:

nested PCR were performed to detect the virus, followed by ssDNA sequencing.

Results:

transplacental transmission of SARS-CoV-2 can cause placental inflammation, ischemia and neonatal viremia, with complications such as preterm labor and damage to the placental barrier in patients with PAI-1 4G/5G mutation.

Conclusion:

we show the possibility of transplacental transmission of SARS-CoV-2 infection during the last weeks of pregnancy.
Subject(s)

Full text: Available Collection: Preprints Database: PREPRINT-RESEARCHSQUARE Main subject: Viremia / COVID-19 / Hypothyroidism / Inflammation / Ischemia / Obstetric Labor, Premature Language: English Year: 2020 Document Type: Preprint

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Full text: Available Collection: Preprints Database: PREPRINT-RESEARCHSQUARE Main subject: Viremia / COVID-19 / Hypothyroidism / Inflammation / Ischemia / Obstetric Labor, Premature Language: English Year: 2020 Document Type: Preprint