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15-Month Health Outcomes of Hospitalized COVID-19 Patients from Onset: A Cohort Study (preprint)
ssrn; 2021.
Preprint
in English
| PREPRINT-SSRN | ID: ppzbmed-10.2139.ssrn.3949426
ABSTRACT
Background:
The long-term impact of COVID-19 on patient health has been a recent focus. This study aims to determine the persistent symptoms and psychological conditions of patients hospitalized with COVID-19 15 months after onset. The potential risk factors were also explored.Methods:
A cohort of COVID-19 patients discharged from February 20, 2020 to March 31, 2020 was recruited. Follow-ups were conducted using validated questionnaires and psychological screening scales at 15 months after onset to evaluate the patients’ health status. The risk factors for long-term health impacts and their associations with disease severity was analyzed.Findings:
534 COVID-19 patients were enrolled. The median age of the patients was 62.0 years old (IQR 52.0-70.0) and 295 were female (55.2%). The median time from onset to follow-up was 460.0 (451.0-467.0) days. Sleep disturbance (18.5%, 99/534) and fatigue (17.2%, 92/534) were the most common persistent symptoms. 6.4% (34/534) of the patients had depression, 9.2% (49/534) were anxious, 13.0% (70/534) had insomnia and 4.7% (25/534) suffered from posttraumatic stress disorder (PTSD). Multivariate adjusted logistic regression analysis showed that glucocorticoid use during hospitalization (OR 3.58, 95% CI 1.12-11.44) was significantly associated with an increased risk of fatigue. The OR values for anxiety and sleep disorders were 2.36 (95% CI 1.07-5.20) and 2.16 (95% CI 1.13-4.14) in females compared with males. The OR value of PTSD was 25.6 (95% CI 3.3-198.4) in patients with persistent symptoms to those without persistent symptoms. No significant associations were observed between fatigue syndrome or adverse mental outcomes and disease severity.Interpretation:
15-month follow-up in this study aroused the need of extended rehabilitation intervention for complete recovery in COVID-19 patients.Funding:
None to declare. Declaration of Interest All the authors declare no competing interests.Ethical Approval The Research Ethics Committee of Shanghai Changzheng Hospital approved this study (2020SL007).
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-SSRN
Main subject:
Anxiety Disorders
/
Stress Disorders, Post-Traumatic
/
Fatigue
/
COVID-19
/
Intellectual Disability
Language:
English
Year:
2021
Document Type:
Preprint
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