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SARS-CoV-2 precipitated Kasabach-Merritt syndrome in a child with Kaposiform Hemangiendothelioma and acute lymphoblastic leukemia (preprint)
authorea preprints; 2021.
Preprint
in English
| PREPRINT-AUTHOREA PREPRINTS | ID: ppzbmed-10.22541.au.163256732.21033830.v1
ABSTRACT
Kaposiform hemangiendothelioma usually occurs in children under two years of age and develops thrombocytopenia secondary to sequestration of platelets within (Kasabach-Merritt phenomenon) and is complicated by secondary consumption of fibrinogen and clotting factors. SARS-CoV-2 produces cutaneous endothelitis as a direct effect of the presence of the virus and the host inflammatory response. We describe an 8-month-old boy with leukemia and SARS-CoV-2 infection who developed Kasabach-Merritt phenomenon, coagulopathy, and intestinal involvement. Given the emerging evidence of endothelial and vascular involvement in COVID-19, the development of tests to detect vascular injury may be critical to guide the use of new therapeutic strategies.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-AUTHOREA PREPRINTS
Main subject:
Thrombocytopenia
/
Leukemia
/
Disseminated Intravascular Coagulation
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Vascular System Injuries
/
Kasabach-Merritt Syndrome
/
COVID-19
Language:
English
Year:
2021
Document Type:
Preprint
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