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Clinical Spectrum and Outcome of Neonatal Multi-System Inflammatory Syndrome (MIS-N) - A Prospective Cohort Study. (preprint)
authorea preprints; 2022.
Preprint in English | PREPRINT-AUTHOREA PREPRINTS | ID: ppzbmed-10.22541.au.166979176.66104074.v1
ABSTRACT

AIMS:

To analyze the clinical spectrum in Neonates with MIS-N based on the time of presentation and also to assess the use of immunomodulator therapy in MIS-N. SUBJECTS AND

METHODS:

We studied 100 neonates, delivered at BLDE (DU) Shri B M Patil Medical College Hospital admitted to Level III-A NICU from JULY 2020 to MAY 2021. 98 neonates had high titers of Ig G antibodies and negative for COVID Antigen. We categorized the cohorts into EARLY MIS-N (<72 hrs) and LATE MIS-N (>72 hrs).

RESULTS:

58 presented as EARLY MIS-N with Respiratory Distress in 40 (70%), cardiac dysfunction 34 (60%), PPHN 12(20%), Fever 12(20%), seizures 12(20%), encephalopathy in 6(10%), sepsis-like features 6(10%), had elevated inflammatory markers like CRP (30%), D-Dimer (70%), Ferritin (30%), cardiac biomarkers like BNP (60%), LDH (30%) and ECHO showing LV dysfunction in 50%. LATE MIS-N presented mostly with fever 28(70%), sepsis-like features 24(60%), Respiratory Distress in 16(40%), cardiac dysfunction 12 (30%), hypoglycemia 4(10%) parotitis 4(10%), had significantly elevated inflammatory markers like CRP (70%), D-Dimer (50%), Ferritin (70%), cardiac biomarkers like BNP (40%), LDH (20%) and ECHO showing LV dysfunction in 20%, dilated coronaries in 20 %, PPHN in 10%. Oxygen and respiratory support requirement was more in EARLY presenters and IVIG and steroid requirement was more in LATE presenters.

CONCLUSION:

We observed that maternal SARS COV2 antibodies transferred transplacentally and neonatal antibodies acquired after COVID 19 infection can cause MIS-N in neonates. The immunomodulator therapy is required in severe cases of MIS-N only.
Subject(s)

Full text: Available Collection: Preprints Database: PREPRINT-AUTHOREA PREPRINTS Main subject: Parotitis / Respiratory Distress Syndrome / Seizures / Sexual Dysfunction, Physiological / Brain Diseases / Dementia, Multi-Infarct / Sepsis / Fever / Heart Diseases / Hypoglycemia Language: English Year: 2022 Document Type: Preprint

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Full text: Available Collection: Preprints Database: PREPRINT-AUTHOREA PREPRINTS Main subject: Parotitis / Respiratory Distress Syndrome / Seizures / Sexual Dysfunction, Physiological / Brain Diseases / Dementia, Multi-Infarct / Sepsis / Fever / Heart Diseases / Hypoglycemia Language: English Year: 2022 Document Type: Preprint