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Genomic Evidence of a SARS-CoV-2 Reinfection Case with E484K Spike Mutation in Brazil (preprint)
preprints.org; 2021.
Preprint
in English
| PREPRINT-PREPRINTS.ORG | ID: ppzbmed-202101.0132.v2
ABSTRACT
To date, uncertainty remains about how long the protective immune responses against SARS-CoV-2 persists and reports of suspected reinfection began to be described in recovered patients months after the first episode. Viral evolution may favor reinfections, and the recently described spike mutations, particularly in the receptor binding domain (RBD) in SARS-CoV-2 lineages circulating in the UK, South Africa, and most recently in Brazil, have raised concern on their potential impact in infectivity, immune escape and reinfection. We report a case of reinfection from distinct SARS-CoV-2 lineages presenting the E484K mutation in Brazil, a variant associated with escape from neutralizing antibodies.
Full text:
Available
Collection:
Preprints
Database:
PREPRINT-PREPRINTS.ORG
Language:
English
Year:
2021
Document Type:
Preprint
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