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Measurement of SARS-CoV-2 RNA in wastewater tracks community infection dynamics.
Peccia, Jordan; Zulli, Alessandro; Brackney, Doug E; Grubaugh, Nathan D; Kaplan, Edward H; Casanovas-Massana, Arnau; Ko, Albert I; Malik, Amyn A; Wang, Dennis; Wang, Mike; Warren, Joshua L; Weinberger, Daniel M; Arnold, Wyatt; Omer, Saad B.
  • Peccia J; Department of Chemical and Environmental Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA. jordan.peccia@yale.edu.
  • Zulli A; Department of Chemical and Environmental Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA.
  • Brackney DE; Connecticut Agricultural Experimental Station, State of Connecticut, New Haven, CT, USA.
  • Grubaugh ND; Department of Epidemiology of Microbial Disease, School of Public Health, Yale University, New Haven, CT, USA.
  • Kaplan EH; Department of Chemical and Environmental Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA.
  • Casanovas-Massana A; Public Health Modeling, Yale School of Public Health, New Haven, CT, USA.
  • Ko AI; School of Management, Yale University, New Haven, CT, USA.
  • Malik AA; Department of Epidemiology of Microbial Disease, School of Public Health, Yale University, New Haven, CT, USA.
  • Wang D; Department of Epidemiology of Microbial Disease, School of Public Health, Yale University, New Haven, CT, USA.
  • Wang M; Yale School of Medicine, New Haven, CT, USA.
  • Warren JL; Yale Institute for Global Health, New Haven, CT, USA.
  • Weinberger DM; Yale School of Medicine, New Haven, CT, USA.
  • Arnold W; Yale School of Medicine, New Haven, CT, USA.
  • Omer SB; Department of Biostatistics, Yale School of Public Health, Yale University, New Haven, CT, USA.
Nat Biotechnol ; 38(10): 1164-1167, 2020 10.
Artículo en Inglés | MEDLINE | ID: covidwho-1023956
ABSTRACT
We measured severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA concentrations in primary sewage sludge in the New Haven, Connecticut, USA, metropolitan area during the Coronavirus Disease 2019 (COVID-19) outbreak in Spring 2020. SARS-CoV-2 RNA was detected throughout the more than 10-week study and, when adjusted for time lags, tracked the rise and fall of cases seen in SARS-CoV-2 clinical test results and local COVID-19 hospital admissions. Relative to these indicators, SARS-CoV-2 RNA concentrations in sludge were 0-2 d ahead of SARS-CoV-2 positive test results by date of specimen collection, 0-2 d ahead of the percentage of positive tests by date of specimen collection, 1-4 d ahead of local hospital admissions and 6-8 d ahead of SARS-CoV-2 positive test results by reporting date. Our data show the utility of viral RNA monitoring in municipal wastewater for SARS-CoV-2 infection surveillance at a population-wide level. In communities facing a delay between specimen collection and the reporting of test results, immediate wastewater results can provide considerable advance notice of infection dynamics.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / ARN Viral / Infecciones por Coronavirus / Pandemias / Aguas Residuales / Betacoronavirus / Monitoreo Epidemiológico Basado en Aguas Residuales Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos País/Región como asunto: America del Norte Idioma: Inglés Revista: Nat Biotechnol Asunto de la revista: Biotecnologia Año: 2020 Tipo del documento: Artículo País de afiliación: S41587-020-0684-z

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / ARN Viral / Infecciones por Coronavirus / Pandemias / Aguas Residuales / Betacoronavirus / Monitoreo Epidemiológico Basado en Aguas Residuales Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos País/Región como asunto: America del Norte Idioma: Inglés Revista: Nat Biotechnol Asunto de la revista: Biotecnologia Año: 2020 Tipo del documento: Artículo País de afiliación: S41587-020-0684-z