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Silent hypoxaemia in COVID-19 patients.
Simonson, Tatum S; Baker, Tracy L; Banzett, Robert B; Bishop, Tammie; Dempsey, Jerome A; Feldman, Jack L; Guyenet, Patrice G; Hodson, Emma J; Mitchell, Gordon S; Moya, Esteban A; Nokes, Brandon T; Orr, Jeremy E; Owens, Robert L; Poulin, Marc; Rawling, Jean M; Schmickl, Christopher N; Watters, Jyoti J; Younes, Magdy; Malhotra, Atul.
  • Simonson TS; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
  • Baker TL; Department of Comparative Biosciences, University of Wisconsin -, Madison, WI, USA.
  • Banzett RB; Division of Pulmonary, Critical Care, & Sleep Medicine Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Bishop T; Target Discovery Institute, University of Oxford, Oxford, UK.
  • Dempsey JA; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin -, Madison, WI, USA.
  • Feldman JL; Department of Neurobiology, University of California, Los Angeles, CA, USA.
  • Guyenet PG; Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, VA, USA.
  • Hodson EJ; The Francis Crick Institute, London, UK.
  • Mitchell GS; The Department of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK.
  • Moya EA; Department of Physical Therapy, Center for Respiratory Research and Rehabilitation, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
  • Nokes BT; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
  • Orr JE; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
  • Owens RL; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
  • Poulin M; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
  • Rawling JM; Departments of Physiology & Pharmacology and Clinical Neurosciences, Cumming School of Medicine and Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.
  • Schmickl CN; Departments of Family Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Watters JJ; Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of California, San Diego, CA, USA.
  • Younes M; Department of Comparative Biosciences, University of Wisconsin -, Madison, WI, USA.
  • Malhotra A; Sleep Disorders Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
J Physiol ; 599(4): 1057-1065, 2021 02.
Artículo en Inglés | MEDLINE | ID: covidwho-1030083
ABSTRACT
The clinical presentation of COVID-19 due to infection with SARS-CoV-2 is highly variable with the majority of patients having mild symptoms while others develop severe respiratory failure. The reason for this variability is unclear but is in critical need of investigation. Some COVID-19 patients have been labelled with 'happy hypoxia', in which patient complaints of dyspnoea and observable signs of respiratory distress are reported to be absent. Based on ongoing debate, we highlight key respiratory and neurological components that could underlie variation in the presentation of silent hypoxaemia and define priorities for subsequent investigation.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: J Physiol Año: 2021 Tipo del documento: Artículo País de afiliación: JP280769

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: J Physiol Año: 2021 Tipo del documento: Artículo País de afiliación: JP280769