Glucose-6-phosphate dehydrogenase deficiency enhances Covid-19 infection in elderly people.
Bratisl Lek Listy
; 121(11): 786-788, 2020.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1034641
ABSTRACT
Our understanding of the mechanisms responsible for death of aged people from Covid-19 became one of the major concerns of these days. Glucose-6-phosphate dehydrogenase (G6PD) enhances the normal senescence and accelerates the precocious removal of chronologically young, yet biologically aged cells. Thus, its deficiency is associated with an increase in the cellular oxidative stress. Accumulating evidence showed that oxidative stress has a fundamental role in several age-related diseases. Nowadays, Covid-19 is considered a serious health problem worldwide. The host cellular environment is the key determinant of pathogen Infectivity. Most respiratory viral infections have a strong association with Glucose-6-phosphate dehydrogenase. Unfortunately, this enzyme deficiency markedly decreases with aging what is involved in increasing of the morbidity rate. The aim of this mini review was to shed more light on the role of G6PD deficiency in aged people infected with Covid-19 (Ref. 20). Keywords GSPD, Covid-19, elderly people.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Neumonía Viral
/
Infecciones por Coronavirus
/
Deficiencia de Glucosafosfato Deshidrogenasa
Tipo de estudio:
Estudio observacional
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Bratisl Lek Listy
Año:
2020
Tipo del documento:
Artículo
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