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Inverse Relationship of Maximal Exercise Capacity to Hospitalization Secondary to Coronavirus Disease 2019.
Brawner, Clinton A; Ehrman, Jonathan K; Bole, Shane; Kerrigan, Dennis J; Parikh, Sachin S; Lewis, Barry K; Gindi, Ryan M; Keteyian, Courtland; Abdul-Nour, Khaled; Keteyian, Steven J.
  • Brawner CA; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI. Electronic address: cbrawne1@hfhs.org.
  • Ehrman JK; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI.
  • Bole S; Public Health Sciences, Henry Ford Health System, Detroit, MI.
  • Kerrigan DJ; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI.
  • Parikh SS; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI.
  • Lewis BK; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI.
  • Gindi RM; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI.
  • Keteyian C; Population Health, Henry Ford Allegiance Health, Jackson, MI.
  • Abdul-Nour K; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI.
  • Keteyian SJ; Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI.
Mayo Clin Proc ; 96(1): 32-39, 2021 01.
Artículo en Inglés | MEDLINE | ID: covidwho-1065435
ABSTRACT

OBJECTIVE:

To investigate the relationship between maximal exercise capacity measured before severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hospitalization due to coronavirus disease 2019 (COVID-19).

METHODS:

We identified patients (≥18 years) who completed a clinically indicated exercise stress test between January 1, 2016, and February 29, 2020, and had a test for SARS-CoV-2 (ie, real-time reverse transcriptase polymerase chain reaction test) between February 29, 2020, and May 30, 2020. Maximal exercise capacity was quantified in metabolic equivalents of task (METs). Logistic regression was used to evaluate the likelihood that hospitalization secondary to COVID-19 is related to peak METs, with adjustment for 13 covariates previously identified as associated with higher risk for severe illness from COVID-19.

RESULTS:

We identified 246 patients (age, 59±12 years; 42% male; 75% black race) who had an exercise test and tested positive for SARS-CoV-2. Among these, 89 (36%) were hospitalized. Peak METs were significantly lower (P<.001) among patients who were hospitalized (6.7±2.8) compared with those not hospitalized (8.0±2.4). Peak METs were inversely associated with the likelihood of hospitalization in unadjusted (odds ratio, 0.83; 95% CI, 0.74-0.92) and adjusted models (odds ratio, 0.87; 95% CI, 0.76-0.99).

CONCLUSION:

Maximal exercise capacity is independently and inversely associated with the likelihood of hospitalization due to COVID-19. These data further support the important relationship between cardiorespiratory fitness and health outcomes. Future studies are needed to determine whether improving maximal exercise capacity is associated with lower risk of complications due to viral infections, such as COVID-19.
Asunto(s)

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Tolerancia al Ejercicio / COVID-19 / Hospitalización Tipo de estudio: Estudios diagnósticos / Estudio experimental / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: Mayo Clin Proc Año: 2021 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Neumonía Viral / Tolerancia al Ejercicio / COVID-19 / Hospitalización Tipo de estudio: Estudios diagnósticos / Estudio experimental / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: Mayo Clin Proc Año: 2021 Tipo del documento: Artículo