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The association between clinical laboratory data and chest CT findings explains disease severity in a large Italian cohort of COVID-19 patients.
Canovi, Simone; Besutti, Giulia; Bonelli, Efrem; Iotti, Valentina; Ottone, Marta; Albertazzi, Laura; Zerbini, Alessandro; Pattacini, Pierpaolo; Giorgi Rossi, Paolo; Colla, Rossana; Fasano, Tommaso.
  • Canovi S; Clinical chemistry and Endocrinology Laboratory, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento 80, 42123, Reggio Emilia, Italy. Simone.Canovi@ausl.re.it.
  • Besutti G; Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
  • Bonelli E; Clinical and Experimental Medicine PhD program, University of Modena and Reggio Emilia, Modena, Italy.
  • Iotti V; Clinical chemistry and Endocrinology Laboratory, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento 80, 42123, Reggio Emilia, Italy.
  • Ottone M; Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
  • Albertazzi L; Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
  • Zerbini A; Epidemiology Unit, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
  • Pattacini P; Clinical chemistry and Endocrinology Laboratory, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento 80, 42123, Reggio Emilia, Italy.
  • Giorgi Rossi P; Laboratory of autoimmunity, allergology and innovative biotechnologies, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
  • Colla R; Radiology Unit, Departement of Diagnostic Imaging and Laboratory Medicine, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
  • Fasano T; Epidemiology Unit, AUSL-IRCCS di Reggio Emilia, viale Risorgimento, 80, 42123, Reggio Emilia, Italy.
BMC Infect Dis ; 21(1): 157, 2021 Feb 08.
Artículo en Inglés | MEDLINE | ID: covidwho-1069549
ABSTRACT

BACKGROUND:

Laboratory data and computed tomography (CT) have been used during the COVID-19 pandemic, mainly to determine patient prognosis and guide clinical management. The aim of this study was to evaluate the association between CT findings and laboratory data in a cohort of COVID-19 patients.

METHODS:

This was an observational cross-sectional study including consecutive patients presenting to the Reggio Emilia (Italy) province emergency rooms for suspected COVID-19 for one month during the outbreak peak, who underwent chest CT scan and laboratory testing at presentation and resulted positive for SARS-CoV-2.

RESULTS:

Included were 866 patients. Total leukocytes, neutrophils, C-reactive protein (CRP), creatinine, AST, ALT and LDH increase with worsening parenchymal involvement; an increase in platelets was appreciable with the highest burden of lung involvement. A decrease in lymphocyte counts paralleled worsening parenchymal extension, along with reduced arterial oxygen partial pressure and saturation. After correcting for parenchymal extension, ground-glass opacities were associated with reduced platelets and increased procalcitonin, consolidation with increased CRP and reduced oxygen saturation.

CONCLUSIONS:

Pulmonary lesions induced by SARS-CoV-2 infection were associated with raised inflammatory response, impaired gas exchange and end-organ damage. These data suggest that lung lesions probably exert a central role in COVID-19 pathogenesis and clinical presentation.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Pulmón Tipo de estudio: Estudio de cohorte / Estudios diagnósticos / Estudio experimental / Estudio observacional / Estudio pronóstico / Investigación cualitativa / Ensayo controlado aleatorizado Límite: Adulto / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Europa Idioma: Inglés Revista: BMC Infect Dis Asunto de la revista: Enfermedades Transmisibles Año: 2021 Tipo del documento: Artículo País de afiliación: S12879-021-05855-9

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Pulmón Tipo de estudio: Estudio de cohorte / Estudios diagnósticos / Estudio experimental / Estudio observacional / Estudio pronóstico / Investigación cualitativa / Ensayo controlado aleatorizado Límite: Adulto / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Europa Idioma: Inglés Revista: BMC Infect Dis Asunto de la revista: Enfermedades Transmisibles Año: 2021 Tipo del documento: Artículo País de afiliación: S12879-021-05855-9