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Hypertension in Patients Hospitalized with COVID-19 in Wuhan, China.
Zhang, Yuan; Sha, Tong; Wu, Feng; Hu, Hongbin; Chen, Zhongqing; Li, Haijun; Han, Jiafa; Song, Wenhong; Huang, Qiaobing; Zeng, Zhenhua.
  • Zhang Y; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University.
  • Sha T; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University.
  • Wu F; Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Basic Medical Sciences, Southern Medical University.
  • Hu H; Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Basic Medical Sciences, Southern Medical University.
  • Chen Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University.
  • Li H; Department of Radiology, Hankou Hospital of Wuhan.
  • Han J; Department of Radiology, Hankou Hospital of Wuhan.
  • Song W; Department of Radiology, Hankou Hospital of Wuhan.
  • Huang Q; Guangdong Provincial Key Laboratory of Shock and Microcirculation, School of Basic Medical Sciences, Southern Medical University.
  • Zeng Z; Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University.
Int Heart J ; 62(2): 337-343, 2021 Mar 30.
Artículo en Inglés | MEDLINE | ID: covidwho-1190190
ABSTRACT
It is unclear whether patients with hypertension are more likely to be infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population and whether there is a difference in the severity of coronavirus disease (COVID-19) pneumonia in patients who have taken ACEI/ARB drugs compared with those who have not.This observational study included data from all patients with clinically confirmed COVID-19 admitted to Hankou Hospital, Wuhan, China, between January 5 and March 8, 2020. Data were extracted from clinical and laboratory records. Follow-up was cut off on March 8, 2020.A total of 274 patients, 75 with hypertension and 199 without hypertension, were included in the analysis. Compared with patients without hypertension, patients with hypertension were older and were more likely to have preexisting comorbidities, including chronic renal insufficiency, cardiovascular disease, diabetes mellitus, and cerebrovascular disease. Moreover, patients with hypertension tended to have higher positive rate for SARS-CoV-2 PCR detection. Multivariate logistic regression analysis showed that age (P = 0.005) and gender (P = 0.019) were independent risk factors associated with the severity of pneumonia in patients on admission, whereas ACEI/ARB treatment (P = 0.184) was not.Patients with COVID-19 with hypertension were significantly older and were more likely to have underlying comorbidities, including chronic renal insufficiency, cardiovascular disease, diabetes mellitus, and cerebrovascular disease. ACEI/ARB drugs did not influence the severity of pneumonia in patients with SARS-CoV-2. In future studies, a larger sample size and multi-center clinical data would be needed to support these conclusions.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Hospitalización / Hipertensión Tipo de estudio: Estudio de cohorte / Estudios diagnósticos / Estudio observacional / Estudio pronóstico Tópicos: Covid persistente Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Asia Idioma: Inglés Revista: Int Heart J Asunto de la revista: Cardiología Año: 2021 Tipo del documento: Artículo

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: COVID-19 / Hospitalización / Hipertensión Tipo de estudio: Estudio de cohorte / Estudios diagnósticos / Estudio observacional / Estudio pronóstico Tópicos: Covid persistente Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Asia Idioma: Inglés Revista: Int Heart J Asunto de la revista: Cardiología Año: 2021 Tipo del documento: Artículo