Severe acute myopathy following SARS-CoV-2 infection: a case report and review of recent literature.
Skelet Muscle
; 11(1): 10, 2021 04 21.
Artículo
en Inglés
| MEDLINE | ID: covidwho-1197351
ABSTRACT
BACKGROUND:
SARS-CoV2 virus could be potentially myopathic. Serum creatinine phosphokinase (CPK) is frequently found elevated in severe SARS-CoV2 infection, which indicates skeletal muscle damage precipitating limb weakness or even ventilatory failure. CASE PRESENTATION We addressed such a patient in his forties presented with features of severe SARS-CoV2 pneumonia and high serum CPK. He developed severe sepsis and acute respiratory distress syndrome (ARDS) and received intravenous high dose corticosteroid and tocilizumab to counter SARS-CoV2 associated cytokine surge. After 10 days of mechanical ventilation (MV), weaning was unsuccessful albeit apparently clear lung fields, having additionally severe and symmetric limb muscle weakness. Ancillary investigations in addition with serum CPK, including electromyogram, muscle biopsy, and muscle magnetic resonance imaging (MRI) suggested acute myopathy possibly due to skeletal myositis.CONCLUSION:
We wish to stress that myopathogenic medication in SARS-CoV2 pneumonia should be used with caution. Additionally, serum CPK could be a potential marker to predict respiratory failure in SARS-CoV2 pneumonia as skeletal myopathy affecting chest muscles may contribute ventilatory failure on top of oxygenation failure due to SARS-CoV2 pneumonia.Palabras clave
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
MEDLINE
Asunto principal:
Cuadriplejía
/
Síndrome de Dificultad Respiratoria
/
Músculo Esquelético
/
Creatina Quinasa
/
COVID-19
/
Enfermedades Musculares
Tipo de estudio:
Reporte de caso
/
Estudios diagnósticos
/
Estudio pronóstico
Tópicos:
Covid persistente
Idioma:
Inglés
Revista:
Skelet Muscle
Año:
2021
Tipo del documento:
Artículo
País de afiliación:
S13395-021-00266-5
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