Your browser doesn't support javascript.
Clinical features and disease severity in an Iranian population of inpatients with COVID-19.
Nabavi, Shima; Javidarabshahi, Zahra; Allahyari, Abolghasem; Ramezani, Mohammad; Seddigh-Shamsi, Mohsen; Ravanshad, Sahar; AkbariRad, Mina; Ebrahimzadeh, Farnoosh; Khatami, Shohre; Emadzadeh, Maryam; Saeedian, Neda; Zarifian, Ahmadreza; Miri, Maryam; Rezaeetalab, Fariba; Hejazi, Sepide; Basiri, Reza; Mozdourian, Mahnaz.
  • Nabavi S; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Javidarabshahi Z; Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Allahyari A; Department of Hematology-Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ramezani M; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Seddigh-Shamsi M; Department of Hematology-Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ravanshad S; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • AkbariRad M; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ebrahimzadeh F; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Khatami S; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Emadzadeh M; Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Saeedian N; Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Zarifian A; Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Miri M; Kidney Transplantation Complications Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Rezaeetalab F; Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Hejazi S; Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Basiri R; Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mozdourian M; Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. mozdorianmh@mums.ac.ir.
Sci Rep ; 11(1): 8731, 2021 04 22.
Artículo en Inglés | MEDLINE | ID: covidwho-1199315
ABSTRACT
Coronavirus disease 2019 (COVID-19) can present with a variety of symptoms. Severity of the disease may be associated with several factors. Here, we review clinical features of COVID-19 inpatients with different severities. This cross-sectional study was performed in Imam Reza hospital, Mashhad, Iran, during February-April 2020. COVID-19 patients with typical computed tomography (CT) patterns and/or positive reverse-transcriptase polymerase chain reaction (RT-PCR) were included. The patients were classified into three groups of moderate, severe, and critical based on disease severity. Demographic, clinical, laboratory, and radiologic findings were collected and compared. P < 0.05 was considered statistically significant. Overall, 200 patients with mean age of 69.75 ± 6.39 years, of whom 82 (41%) were female were studied. Disease was severe/critical in the majority of patients (167, 83.5%). Disease severity was significantly associated with age, malignant comorbidities, dyspnea, nausea/vomiting, confusion, respiratory rate, pulse rate, O2 saturation, extent of CT involvement, serum C-reactive protein (CRP), pH, pO2, and aspartate transaminase (P < 0.05). Moreover, complications including shock, coagulopathy, acidosis, sepsis, acute respiratory distress syndrome (ARDS), intensive care unit (ICU) admission, and intubation were significantly higher in patients with higher severities (P < 0.05). O2 saturation, nausea/vomiting, and extent of lung CT involvement were independent predictors of severe/critical COVID-19 (OR 0.342, 45.93, and 25.48, respectively; P < 0.05). Our results indicate O2 saturation, nausea/vomiting, and extent of lung CT involvement as independent predictors of severe COVID-19 conditions. Serum CRP levels and pO2 were also considerably higher patients with higher severity and can be used along with other factors to predict severe disease in COVID-19 patients.
Asunto(s)

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / COVID-19 Tipo de estudio: Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Anciano / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Asia Idioma: Inglés Revista: Sci Rep Año: 2021 Tipo del documento: Artículo País de afiliación: S41598-021-87917-1

Similares

MEDLINE

...
LILACS

LIS


Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / COVID-19 Tipo de estudio: Estudio experimental / Estudio observacional / Estudio pronóstico / Ensayo controlado aleatorizado Límite: Anciano / Femenino / Humanos / Masculino / Middle aged País/Región como asunto: Asia Idioma: Inglés Revista: Sci Rep Año: 2021 Tipo del documento: Artículo País de afiliación: S41598-021-87917-1