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A review of significance of Aspergillus detection in airways of ICU COVID-19 patients.
Pasquier, Grégoire; Bounhiol, Agathe; Robert Gangneux, Florence; Zahar, Jean-Ralph; Gangneux, Jean Pierre; Novara, Ana; Bougnoux, Marie-Elisabeth; Dannaoui, Eric.
  • Pasquier G; Microbiology Department, Parasitology-Mycology Unit, Faculty of Medicine, Paris University, Necker-Enfants maladies Hospital, Paris, France.
  • Bounhiol A; Microbiology Department, Parasitology-Mycology Unit, Faculty of Medicine, Paris University, AP-HP, European Georges-Pompidou Hospital, Paris, France.
  • Robert Gangneux F; Parasitology-Mycology Department, Centre Hospitalier Universitaire de Rennes, Rennes, France.
  • Zahar JR; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, University Rennes, Rennes, France.
  • Gangneux JP; Infection Control Unit, Avicenne Hospital, Bobigny, France.
  • Novara A; Parasitology-Mycology Department, Centre Hospitalier Universitaire de Rennes, Rennes, France.
  • Bougnoux ME; Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, University Rennes, Rennes, France.
  • Dannaoui E; Medical Intensive Care Unit, Faculty of Medicine, Paris-Descartes University, AP-HP, European Georges-Pompidou Hospital, Paris, France.
Mycoses ; 64(9): 980-988, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: covidwho-1273123
Información semántica de SemMedBD (por NLM)
1. COVID-19 PROCESS_OF Patients
Sujeto
COVID-19
Predicado
PROCESS_OF
Objeto
Patients
2. Airway structure PART_OF Patients
Sujeto
Airway structure
Predicado
PART_OF
Objeto
Patients
3. Invasive Pulmonary Aspergillosis COEXISTS_WITH Patient ventilated
Sujeto
Invasive Pulmonary Aspergillosis
Predicado
COEXISTS_WITH
Objeto
Patient ventilated
4. Invasive Pulmonary Aspergillosis PROCESS_OF Patients
Sujeto
Invasive Pulmonary Aspergillosis
Predicado
PROCESS_OF
Objeto
Patients
5. Colonization PROCESS_OF Patients
Sujeto
Colonization
Predicado
PROCESS_OF
Objeto
Patients
6. COVID-19 PROCESS_OF Patients
Sujeto
COVID-19
Predicado
PROCESS_OF
Objeto
Patients
7. Airway structure PART_OF Patients
Sujeto
Airway structure
Predicado
PART_OF
Objeto
Patients
8. Invasive Pulmonary Aspergillosis COEXISTS_WITH Patient ventilated
Sujeto
Invasive Pulmonary Aspergillosis
Predicado
COEXISTS_WITH
Objeto
Patient ventilated
9. Invasive Pulmonary Aspergillosis PROCESS_OF Patients
Sujeto
Invasive Pulmonary Aspergillosis
Predicado
PROCESS_OF
Objeto
Patients
10. Colonization PROCESS_OF Patients
Sujeto
Colonization
Predicado
PROCESS_OF
Objeto
Patients
ABSTRACT
It is now well known that patients with SARS-CoV-2 infection admitted in ICU and mechanically ventilated are at risk of developing invasive pulmonary aspergillosis (IPA). Nevertheless, symptomatology of IPA is often atypical in mechanically ventilated patients, and radiological aspects in SARS-CoV-2 pneumonia and IPA are difficult to differentiate. In this context, the significance of the presence of Aspergillus in airway specimens (detected by culture, galactomannan antigen or specific PCR) remains to be fully understood. To decipher the relevance of the detection of Aspergillus, we performed a comprehensive review of all published cases of respiratory Aspergillus colonisation and IPA in COVID-19 patients. The comparison of patients receiving or not antifungal treatment allowed us to highlight the most important criteria for the decision to treat. The comparison of surviving and non-surviving patients made it possible to unveil criteria associated with mortality that should be taken into account in the treatment decision.
Asunto(s)

Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo del documento: Artículo Asunto principal: Líquido del Lavado Bronquioalveolar / Causas de Muerte / Aspergilosis Pulmonar Invasiva / COVID-19 / Antifúngicos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronostico Idioma: Inglés Revista: Mycoses Aspecto clínico: Diagnóstico / Etiología / Terapia Año: 2021

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Tipo del documento: Artículo Asunto principal: Líquido del Lavado Bronquioalveolar / Causas de Muerte / Aspergilosis Pulmonar Invasiva / COVID-19 / Antifúngicos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronostico Idioma: Inglés Revista: Mycoses Aspecto clínico: Diagnóstico / Etiología / Terapia Año: 2021
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