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Does the COVID-19 seroconversion in older adults resemble the young?
Bag Soytas, Rabia; Cengiz, Mahir; Islamoglu, Mehmet Sami; Uysal, Betul Borku; Ikitimur, Hande; Yavuzer, Hakan; Yavuzer, Serap.
  • Bag Soytas R; Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Cengiz M; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
  • Islamoglu MS; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
  • Uysal BB; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
  • Ikitimur H; Department of Pulmonary Diseases, Biruni University Medical Faculty, Istanbul, Turkey.
  • Yavuzer H; Division of Geriatrics, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Yavuzer S; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
J Med Virol ; 93(10): 5777-5782, 2021 Oct.
Artículo en Inglés | MEDLINE | ID: covidwho-1432408
ABSTRACT
High antibody titers have been found to correlate with the severity of coronavirus disease 2019 (COVID-19) disease. Therefore, antibody titers may be higher in older adults, whose disease is known to have a more severe course than younger ones. This study aimed to compare the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) antibody level in the reverse transcription-polymerase chain reaction (RT-PCR) to test positive older adults with young. Patients aged ≥18 with positive RT-PCR and checked serum IgG antibodies between November 1, 2020 and January 13, 2021 were included. The IgG antibody levels and the time between RT-PCR positivity with the antibody levels were recorded. A total of 1071 patients were divided into two groups as Group 1 <60 years old (n = 902) and Group 2 ≥60 years old (n = 169). The SARS-CoV-2 IgG antibody titers were higher in Group 2 (p = 0.001). This height was present in the first 3 months after positive RT-PCR. While the antibody titers were compared by dividing Group 2 into the three groups according to age ranges (60-69, 70-79, and ≥80 years), the antibody titer was higher in ≥80 years patients (p = 0.044). High COVID-19 IgG antibody levels may be associated with the severity of the disease. Also, the humoral immunity advantage was seen in the first 3 months in the older patients, which suggests that older adults with COVID-19 may develop reinfection in the long term.
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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Seroconversión / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudios diagnósticos / Estudio experimental / Estudio pronóstico / Ensayo controlado aleatorizado Tópicos: Covid persistente Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: J Med Virol Año: 2021 Tipo del documento: Artículo País de afiliación: Jmv.27106

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Texto completo: Disponible Colección: Bases de datos internacionales Base de datos: MEDLINE Asunto principal: Seroconversión / SARS-CoV-2 / COVID-19 Tipo de estudio: Estudios diagnósticos / Estudio experimental / Estudio pronóstico / Ensayo controlado aleatorizado Tópicos: Covid persistente Límite: Adulto / Anciano / Femenino / Humanos / Masculino / Middle aged Idioma: Inglés Revista: J Med Virol Año: 2021 Tipo del documento: Artículo País de afiliación: Jmv.27106